FR 409
FR 409 (NOR3) is a NO donor and vasodilator. FR 409 increases the diameter of retinal arterioles. FR 409 is toxic to a variety of cells. FR 409 can be used in research on pain and retinopathy.
For research use only. We do not sell to patients.
- CAS No.: 138472-01-2
- Formula: C8H13N3O4
- Molecular Weight:215.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FR 409 (50-100 μM; 17-25 h) is toxic to PC12, NIH-3T3, and MDA-MB-231 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
FR 409 (0.5–10 µg/kg/min; i.v.; single dose) increases the diameter of retinal arterioles and decreases mean arterial pressure in rats in a dose-dependent manner[3].
FR 409 (5 nM/eye; i.v.; single dose) increases the diameter of retinal arterioles in Wistar rats, but does not change mean arterial pressure or heart rate[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (Male, 7-10 weeks old)[1]
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Dosage:2 mM
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Administration:i.t.; single dose
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Result:Induced cortical enhancement and mechanical hyperalgesia.
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Animal Model:Wistar rats (male, 7–9 weeks old)[4]
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Dosage:5 nM/eye
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Administration:i.v.; single dose
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Result:Increased the retinal arteriolar diameter without changing the mean arterial pressure and heart rate.
Chemical Information
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CAS No. 138472-01-2
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Molecular Weight 215.21
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Formula C8H13N3O4
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SMILES
NC(C(/C=C(CC)/C([N+]([O-])=O)C)=N/O)=O
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Synonyms
NOR 3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Onishi T, et al. Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. J Physiol. 2019 Jul;597(13):3441-3455. [Content Brief]
[2]. Tsurukawa Y, et al. Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound. ACS Omega. 2025 Oct 8;10(41):49243-49251. [Content Brief]
[3]. Mori A, et al. 4-Aminopyridine, a Voltage-Gated K+ Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats. Biol Pharm Bull. 2020;43(7):1123-1127. [Content Brief]
[4]. Mori A, et al. Role of Prostaglandins in Nitric Oxide-Induced Glial Cell-Mediated Vasodilation in Rat Retina. Biomolecules. 2022 Oct 1;12(10):1403. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR 409 Related Classifications
HY-110057 Related Classifications
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