iNOS inhibitor-10
iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM). iNOS inhibitor-10 has antiproliferative effect against triple negative breast cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2918773-63-2
- Formula: C22H23N3O2S
- Molecular Weight:393.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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iNOS 0.065 μM (IC50) |
eNOS >50 μM (IC50) |
iNOS inhibitor-10 (Compound 1b, 1 μM) inhibits iNOS activity by 83%, and is inactive against eNOS[1].
iNOS inhibitor-10 (0.001-100 μM, 5 days) reduces cell viability of MDA-MB-231 cells[1].
iNOS inhibitor-10 (25 μM, 24 h) prevents migration of MDA-MB-231 cells[1].
iNOS inhibitor-10 (measured in liver microsomes) shows a reasonably metabolic stability, with a t1/2 of 38 min CLint of 39.6 mL/min/Kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:0.001-100 μM
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Incubation Time:5 days
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Result:Inhibited cell viability with an EC50 value of 24.71 μM.
Chemical Information
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CAS No. 2918773-63-2
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Molecular Weight 393.50
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Formula C22H23N3O2S
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SMILES
CC1=CC=C(C=C1)S(=O)(NCC2=CC(CNC(C3=CC=CC=C3)=N)=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iNOS inhibitor-10 Related Classifications
HY-152536 Related Classifications
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