PKC Inhibitor

PKC Inhibitors (320):

Cat. No.	Nom du produit	Effet	Pureté

HY-N6734

K-252b	Inhibitor
K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .

HY-12880

HA-100 dihydrochloride	Inhibitor
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor.

HY-108136

Bisindolylmaleimide X	Inhibitor
Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC₅₀ of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases.

HY-P1286A

PKC β pseudosubstrate TFA	Inhibitor
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC.

HY-P1399

Pep2m, myristoylated	Inhibitor
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).

HY-P1289C

[Ala113]MBP(104-118) TFA	Inhibitor
[Ala113]MBP(104-118) TFA is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC₅₀s ranging from 28-62 μM.

HY-114554

KS 619-1	Inhibitor
KS 619-1 is a Ca²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus.

HY-P3083

N-Myristoyl-Lys-Arg-Thr-Leu-Arg	Inhibitor
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC₅₀ value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat.

HY-RS11146

Prkd1 Rat Pre-designed siRNA Set A	Inhibitor
Prkd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-112681B

PKC-theta inhibitor 2 hydrochloride	Inhibitor
PKC-theta inhibitor 2 hydrochloride is a potent and selective PKC-θ inhibitor with an IC₅₀ value of 18 nM.

HY-RS11122

PRKCD Human Pre-designed siRNA Set A	Inhibitor
PRKCD Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11121

Prkcb Rat Pre-designed siRNA Set A	Inhibitor
Prkcb Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-155619

Protein kinase inhibitor 7	Inhibitor
Protein kinase inhibitor 7 is an inhibitor for protein kinase A and protein kinase C. Protein kinase inhibitor 7 affects autocrine motility factor (AMF) signaling pathway, without affecting the cell motility.

HY-W782599

Senkyunolide B	Inhibitor
Senkyunolide B is a phthalide found in Angelica sinensis. Senkyunolide B has broad antifungal activities. Senkyunolide B affects the spore germination and hyphae growth of Aspergillus fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis and the expression of ENG genes.

HY-13502S

Mitoxantrone-d₈	Inhibitor
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM.

HY-RS11129

Prkcg Mouse Pre-designed siRNA Set A	Inhibitor
Prkcg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11130

Prkcg Rat Pre-designed siRNA Set A	Inhibitor
Prkcg Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-N12466

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine	Inhibitor
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC₅₀s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC₅₀ value of 0.16 μM.

HY-N0281R

Daphnetin (Standard)	Inhibitor
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

HY-RS11118

Prkca Rat Pre-designed siRNA Set A	Inhibitor
Prkca Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkca gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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