1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Pep2m, myristoylated

Pep2m, myristoylated (Synonyms: Myr-Pep2m)

Cat. No.: HY-P1399
Handling Instructions

Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions.

For research use only. We do not sell to patients.

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Pep2m, myristoylated Chemical Structure

Pep2m, myristoylated Chemical Structure

CAS No. : 1423381-07-0

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Description

Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions[1][2].

IC50 & Target

NSF/GluR2 interactions[1]

In Vitro

Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation[1].
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis[1].
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Long-Evans hooded rats (8 weeks)[2]
Dosage: 10 µg (in 20 µL)
Administration: Intrathecal injection
Result: Resulted in an increase in PWTs, in both male and female rats at various time points tested.
Molecular Weight

1383.81

Formula

C₆₃H₁₁₈N₁₈O₁₄S

CAS No.

1423381-07-0

Sequence Shortening

{Myr}-KRMKVAKNAQ

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pep2m, myristoylatedMyr-Pep2mPKCProtein kinase Clong-termmemoryPKMζNSFGluR2spinalnociceptivesensitizationInhibitorinhibitorinhibit

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Pep2m, myristoylated
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