1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Pep2m, myristoylated TFA

Pep2m, myristoylated TFA (Synonyms: Myr-Pep2m TFA)

Cat. No.: HY-P1399A Purity: 99.77%
Handling Instructions

Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).

For research use only. We do not sell to patients.

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Pep2m, myristoylated TFA Chemical Structure

Pep2m, myristoylated TFA Chemical Structure

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2].

IC50 & Target

NSF/GluR2 interactions[1]

In Vitro

Pep2m, myristoylated TFA (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation[1].
Pep2m, myristoylated TFA does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis[1].
Pep2m, myristoylated TFA blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pep2m, myristoylated TFA (10 µg/20 µL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Long-Evans hooded rats (8 weeks)[2]
Dosage: 10 µg (in 20 µL)
Administration: Intrathecal injection
Result: Resulted in an increase in PWTs, in both male and female rats at various time points tested.
Molecular Weight

1497.83

Formula

C₆₅H₁₁₉F₃N₁₈O₁₆S

Sequence Shortening

{Myr}-KRMKVAKNAQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References
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Keywords:

Pep2m, myristoylatedMyr-Pep2mPKCProtein kinase Clong-termmemoryPKMζNSFGluR2spinalnociceptivesensitizationInhibitorinhibitorinhibit

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Pep2m, myristoylated TFA
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