KS 619-1
KS 619-1 is a Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus.
For research use only. We do not sell to patients.
- CAS No.: 103370-21-4
- Formula: C26H18O9
- Molecular Weight:474.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
KS 619-1 potently inhibits Ca2+/calmodulin-stimulated bovine brain CaM-PDE with an IC50 of 2.0 μM[1].
KS 619-1 potently inhibits Ca2+/calmodulin-activated bovine cardiac CaM-PDE with an IC50 of 1.5 μM[1].
KS 619-1 weakly inhibits the activity of bovine brain basal CaM-PDE (in the presence of EGTA), with an IC50 value of 12.3 μM[1].
KS 619-1 weakly inhibits calmodulin-independent PDE activity in bovine cardiac muscle, with an IC50 of 25.9 μM[1].
KS 619-1 exhibits extremely weak inhibitory activity against rat brain protein kinase C, with an IC50 of 151 μM[1].
KS 619-1 (50 μg/mL) exhibits only weak antibacterial activity against Staphylococcus aureus KY 4779[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103370-21-4
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Molecular Weight 474.42
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Formula C26H18O9
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SMILES
O=C(O)C1=C(O)C=2C3=CC=4C(=O)C=5C=C(O)C=C(O)C5C(=O)C4C(O)=C3CCC2C=C1CC(=O)C
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Initial Source
from Streptomyces californicus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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