2. Metabolic Enzyme/Protease TGF-beta/Smad Epigenetics Anti-infection
  3. Phosphodiesterase (PDE) PKC Bacterial
  4. KS 619-1

KS 619-1 is a Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus.

For research use only. We do not sell to patients.

KS 619-1

KS 619-1 Chemical Structure

CAS No. : 103370-21-4

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KS 619-1 Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

KS 619-1 is a Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus[1].

In Vitro

KS 619-1 potently inhibits Ca2+/calmodulin-stimulated bovine brain CaM-PDE with an IC50 of 2.0 μM[1].
KS 619-1 potently inhibits Ca2+/calmodulin-activated bovine cardiac CaM-PDE with an IC50 of 1.5 μM[1].
KS 619-1 weakly inhibits the activity of bovine brain basal CaM-PDE (in the presence of EGTA), with an IC50 value of 12.3 μM[1].
KS 619-1 weakly inhibits calmodulin-independent PDE activity in bovine cardiac muscle, with an IC50 of 25.9 μM[1].
KS 619-1 exhibits extremely weak inhibitory activity against rat brain protein kinase C, with an IC50 of 151 μM[1].
KS 619-1 (50 μg/mL) exhibits only weak antibacterial activity against Staphylococcus aureus KY 4779[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KS 619-1 Related Antibodies
Molecular Weight

474.42

Formula

C26H18O9
CAS No.
SMILES

O=C(O)C1=C(O)C=2C3=CC=4C(=O)C=5C=C(O)C=C(O)C5C(=O)C4C(O)=C3CCC2C=C1CC(=O)C
Structure Classification
Initial Source

from Streptomyces californicus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KS 619-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS 619-1103370-21-4Phosphodiesterase (PDE)PKCBacterialProtein kinase Cbovine brain CaM-PDErat brain protein kinase CCandida albicansStaphylococcus aureusbovine heart CaM-independent cyclic nucleotide phosphodiesterasebovine heart CaM-PDEInhibitorinhibitorinhibit

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