Phospholipase
Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.
Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.
Phospholipase Isoform Specific Products
All Product Categories
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Phospholipase Related Products (326)
Related Products (326)
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Antibodies (9)
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Phospholipase Isoform Comparison
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AVX001
0 ImagesCat. No.: HY-19920CAS No.: 300553-18-8Synonyms: AKH-217AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis.
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Rilapladib (Standard)
0 ImagesCat. No.: HY-102004RCAS No.: 412950-08-4Synonyms: SB 659032 (Standard)Rilapladib (Standard) is the analytical standard of Rilapladib (HY-102004). This product is intended for research and analytical applications. Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist.
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PACOCF3 (Standard)
0 ImagesCat. No.: HY-108607RCAS No.: 141022-99-3Synonyms: Palmityltrifluoromethylketone (Standard)PACOCF3 (Standard) is the analytical standard of PACOCF3. This product is intended for research and analytical applications. PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
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PF-04217903 phosphate
0 ImagesCat. No.: HY-12017CCAS No.: 1159490-83-1PF-04217903 phosphate is an orally active, highly selective ATP-competitive c-Met kinase inhibitor with a Ki value of 4.8 nM and a Kd value of 4.5 nM. PF-04217903 phosphate blocks c-Met and HGF signaling pathways, inhibits MET phosphorylation, and blocks downstream MAPK, PI3K/AKT and PLCγ1 pathways. PF-04217903 phosphate suppresses tumor proliferation, survival, migration, invasion, angiogenesis and metastasis, induces apoptosis, and enhances efferocytosis, Annexin A1 expression and resolution of inflammation. PF-04217903 phosphate retains activity against several c-Met mutants (M1131T, V1220I, H1094R). PF-04217903 phosphate increases the incidence of subarachnoid hemorrhage and reduces survival rate without altering aneurysm formation, and also prevents lymph node metastasis induced by VEGF inhibition. PF-04217903 phosphate is applicable to research related to tumors (pancreas, stomach, lung, brain, colon, breast, kidney, melanoma, etc.), intracranial aneurysms and inflammatory diseases (gouty arthritis, neutrophilic pleuritis).
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(S)-Albuterol
0 ImagesCat. No.: HY-137311ACAS No.: 34271-50-6(S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
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U-73343 (Standard)
0 ImagesCat. No.: HY-108630RCAS No.: 142878-12-4U-73343 (Standard) is the analytical standard of U-73343 (HY-108630). This product is intended for research and analytical applications. U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
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Chlorogentisylquinone
0 ImagesCat. No.: HY-N15058CAS No.: 333344-08-4Chlorogentisylquinone is found in the strain of FOM-8108. The IC50 of inhibitory rat meningeal nSMase is 1.2 μM, and the IC50 of P388 cells is 7.6 μM.
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Phosphatidylinositol 4,5-bisphosphate
0 ImagesCat. No.: HY-114457CAS No.: 245126-95-8Synonyms: L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABAA receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema.
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Cambinol (Standard)
0 ImagesCambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
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1-Linoleoyl Glycerol (Standard)
0 ImagesCat. No.: HY-111346RCAS No.: 2277-28-3Synonyms: 1-Linoleoyl-rac-glycerol (Standard); 1-Monolinolein (Standard)1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
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Cinatrin C2
0 ImagesCat. No.: HY-N14104CAS No.: 136266-36-9Cinatrin C2 is a phospholipase A2 (PLA2) inhibitor with an IC50 of 800 μM and can be extracted from Circinotrichum falcatisporum RF-641.
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BAPTA tetracesium
0 ImagesCat. No.: HY-W778574CAS No.: 480436-84-8BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
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ASM-IN-3
0 ImagesCat. No.: HY-171033CAS No.: 2342576-75-2
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Goxalapladib
0 ImagesCat. No.: HY-169114CAS No.: 412950-27-7Goxalapladib is a 5-HT6 receptor modulator that blocks lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. Goxalapladib is promising for research of atherosclerosis-associated cardiovascular diseases.
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3-Nitrocoumarin (Standard)
0 ImagesCat. No.: HY-111919RCAS No.: 28448-04-63-Nitrocoumarin (Standard) is the analytical standard of 3-Nitrocoumarin (HY-111919). This product is intended for research and analytical applications. 3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway.
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VU0155069 (Standard)
0 ImagesCat. No.: HY-108612RCAS No.: 1130067-06-9Synonyms: CAY10593 (Standard)VU0155069 (Standard) is the analytical standard of VU0155069 (HY-108612). This product is intended for research and analytical applications. VU0155069 (CAY10593), is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays.
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1-Naphthaleneacetic acid (Standard)
0 Images1-Naphthaleneacetic acid (Standard) is the analytical standard of 1-Naphthaleneacetic acid. This product is intended for research and analytical applications. 1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.
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SMase-IN-1
0 ImagesCat. No.: HY-170650CAS No.: 33017-85-5SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
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m-3M3FBS (Standard)
0 Imagesm-3M3FBS (Standard) is the analytical standard of m-3M3FBS. This product is intended for research and analytical applications. m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis.
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Cinatrin C3
0 ImagesCat. No.: HY-N14105CAS No.: 136266-37-0Cinatrin C3 is a phospholipase A2 (PLA2) inhibitor with an IC50 of 70 μM and can be extracted from Circinotrichum falcatisporum RF-641.
