VU0155056

Cat. No.: HY-W414803: Data Sheet Handling Instructions
FAQs
Technical Support

VU0155056 is a cell-permeable phospholipase D inhibitor.

For research use only. We do not sell to patients.

VU0155056 Chemical Structure

CAS No. : 1130067-18-3

Size	Stock	Quantity
5 mg	Get quote 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
25 mg	Get quote 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

Synthetic products have potential research and development risk.

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Phospholipase Isoform Specific Products:

View All Isoforms

Phospholipase A PLD Phospholipase C

Biological Activity
Purity & Documentation
References
Customer Review

Description

VU0155056 is a cell-permeable phospholipase D inhibitor.

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-1	IC₅₀	21 nM Compound: 2	Inhibition of human PLD1 in Calu1 cells Inhibition of human PLD1 in Calu1 cells	[PMID: 19268584]
Calu-1	IC₅₀	21 nM Compound: 56	Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis	[PMID: 19136975]
HEK293	IC₅₀	380 nM Compound: 2	Inhibition of GFP-labelled human PLD2 HEK293 cells Inhibition of GFP-labelled human PLD2 HEK293 cells	[PMID: 19268584]
HEK293	IC₅₀	380 nM Compound: 56	Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis	[PMID: 19136975]

Molecular Weight

414.51

Formula

C₂₅H₂₆N₄O₂

CAS No.

1130067-18-3

SMILES

O=C(NCCN1CCC(N2C(=O)NC=3C=CC=CC32)CC1)C=4C=CC=5C=CC=CC5C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tsai YR, et al. Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):507-19. [Content Brief]

[2]. McDavid S, Bauer MB, Brindley RL, Jewell ML, Currie KP. Butanol isomers exert distinct effects on voltage-gated calcium channel currents and thus catecholamine secretion in adrenal chromaffin cells. PLoS One. 2014;9(10):e109203. Published 2014 Oct 2. [Content Brief]

[3]. Tsai YR, Huang LJ, Lin HY, et al. Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(6):507-519. [Content Brief]

VU0155056 Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU01550561130067-18-3VU 0155056VU-0155056PhospholipaseLipidInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *