ROR
RAR-related orphan receptor
Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and belonging to the orphan nuclear receptor family. The ROR subfamily contains three members: RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) and function as ligand-dependent transcription factors.
RORs are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis.
RORα and RORγ are important regulators of the immune system. The development and differentiation of Th17 cells are dependent on these factors. RORγ is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and γδ T cells, which contribute to inflammation and autoimmune disease.
ROR Isoform Specific Products
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ROR Inhibitors
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ROR Agonists
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ROR Antagonists
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ROR Activators
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ROR Modulators
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ROR Inducer
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ROR Degraders
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ROR Control
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ROR Ligands
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ROR Related Products (148)
Related Products (148)
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Antibodies (5)
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ROR Isoform Comparison
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RORγt inhibitor 2
0 ImagesCat. No.: HY-142934CAS No.: 2673278-10-7RORγt inhibitor 2 (Compound 119) is a potent RORγt inhibitor with an IC50 of 9.2 nM. RORγt inhibitor 2 can be used for the research of cancer, inflammation or autoimmune diseases mediated by RORγt.
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Gala-SR
0 ImagesCat. No.: HY-179514CAS No.: 3092129-97-7Synonyms: Gala-SR1078Gala-SR (Gala-SR1078) is an RORα agonist. Gala-SR ameliorates rhythm disorders by enhancing the amplitude of the circadian rhythm. Gala-SR can be used for the study of periodontitis.
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CD12681
0 ImagesCat. No.: HY-111366CAS No.: 1952239-59-6
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Rorb Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12130Rorb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rorb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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SR1555 hydrochloride
0 ImagesCat. No.: HY-120785ACAS No.: 2309312-90-9SR1555 hydrochloride is the hydrochloride salt form of SR1555 (HY-120785). SR1555 hydrochloride is an inverse agonist for retinoic acid receptor-related orphan nuclear receptor γ (RORγ) with an IC50 of 1 μM. SR1555 hydrochloride inhibits the development and function of pro-inflammatory TH17 cell, increases the frequency of anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride can be used for research about autoimmune diseases.
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Nobiletin (Standard)
0 ImagesNobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.
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RORγ-IN-2
0 ImagesCat. No.: HY-W545294CAS No.: 2088333-58-6RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases.
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RORγt inverse agonist 36
0 ImagesCat. No.: HY-177712CAS No.: 1599530-54-7RORγt inverse agonist 36 (S configuration of Compound 16) is a RORγt inverse agonist. RORγt inverse agonist 36 can be used for the research of inflammation and immunology.
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ROR1-IN-4
0 ImagesCat. No.: HY-175497ROR1-IN-4 is a selective ROR1 inhibitor with a Kd of 52 nM. ROR1-IN-4 shows potent anti-proliferative activity against TNBC cell line MDA-MB-231 (IC50 = 75 nM). ROR1-IN-4 reduces colony formation, induces apoptosis and inhibits the phosphorylation of ROR1 (Tyr786) in MDA-MB-231 cells. ROR1-IN-4 demonstrates superior anti-tumor efficacy in nude mice bearing MDA-MB-231 subcutaneous xenografts. ROR1-IN-4 can be used for the study of triple-negative breast cancer (TNBC).
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RORγ-IN-4
0 ImagesCat. No.: HY-183145CAS No.: 1608139-41-8RORγ-IN-4 is a RORγ inhibitor with an EC50 of 0.014 μM. RORγ-IN-4 can be used for the research of inflammation.
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RORγt inverse agonist 30
0 ImagesCat. No.: HY-147533CAS No.: 1445901-41-6RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders.
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NP1
0 ImagesCat. No.: HY-P11859NP1 is a NOTA-chelated linear precursor based on the ROR1-targeting peptide. After labeling with [18F]AlF, NP1 yields [18F]AlF-NP1, a PET imaging probe with excellent ROR1 specificity (KD = 141.7 nM), rapid tumor uptake and high target-to-background ratio, which is suitable for non-invasive visualization of various ROR1-overexpressing tumors.
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Zymostenol (Standard)
0 ImagesCat. No.: HY-113345RCAS No.: 566-97-2Synonyms: 5a-Cholest-8-en-3b-ol (Standard)Oxyphenbutazone (monohydrate) (Standard) is the analytical standard of Oxyphenbutazone (monohydrate). This product is intended for research and analytical applications. Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis.
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RORγt inverse agonist 38
0 ImagesCat. No.: HY-184876CAS No.: 2891663-21-9
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RORC modulator-1
0 ImagesCat. No.: HY-180865CAS No.: 919974-50-8RORC modulator-1 (example 119) is a RORC modulator.
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TMP780 (Standard)
0 ImagesCat. No.: HY-102075BRCAS No.: 1422053-03-9TMP780 (Standard) is the analytical standard of TMP780 (HY-102075B). This product is intended for research and analytical applications. TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders.
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CID 7309015
0 ImagesCat. No.: HY-129338CAS No.: 1164457-99-1CID 7309015 is an inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). CID 7309015 can be used for research of inflammation, NF-κB signaling or inflammatory arthritis.
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Cintirorgon (Standard)
0 ImagesSynonyms: LYC-55716 (Standard)Cintirorgon (Standard) is the analytical standard of Cintirorgon (HY-104037). This product is intended for research and analytical applications. Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.
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RORγt inhibitor 3
0 ImagesCat. No.: HY-112863CAS No.: 1361413-10-6RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models.
