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Cat. No.: HY-183145

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RORγ-IN-4

RORγ-IN-4 is a RORγ inhibitor with an EC₅₀ of 0.014 μM. RORγ-IN-4 can be used for the research of inflammation.

For research use only. We do not sell to patients.

CAS No.: 1608139-41-8
Formula: C₂₆H₃₀ClN₃O₅
Molecular Weight:499.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RORγ-IN-4 Chemical Structure

CAS No.: 1608139-41-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

RORγ-IN-4 is a RORγ inhibitor with an EC₅₀ of 0.014 μM. RORγ-IN-4 can be used for the research of inflammation^[1].

IC₅₀ & Target^[1]

RORγ

0.014 μM (EC₅₀)

All ROR Isoforms :

In Vitro

RORγ-IN-4 (non-salt form of Compound 12) potently inhibits RORγ in a luciferase reporter assay with an EC₅₀ of 0.014 μM, exhibits favorable metabolic stability in human liver microsomes, and demonstrates high apparent permeability in Caco2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1608139-41-8
Molecular Weight 499.99
Formula C₂₆H₃₀ClN₃O₅
SMILES

ClC(C=C(C=C1)C)=C1NC(C[C@@H](C2=NOC(C3=NOC(CC(C)C)=C3)=C2C4CC4)CCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kotoku M, et al. Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold. J Med Chem. 2019;62(5):2837-2842. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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RORγ-IN-4

All ROR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RORγ-IN-4 Related Classifications

HY-183145 Related Classifications