2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Telomerase

Telomerase

Telomerase

Related Products

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Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) containing a specialized telomerase reverse transcriptase (TERT) and telomerase RNA (TER) with its own template and other elements required with TERT for activity (catalytic core), as well as species-specific TER-binding proteins important for biogenesis and assembly (core RNP); other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere ends for regulation of DNA synthesis.

Telomerase activity is responsible for the maintenance of chromosome end structures (telomeres) and cancer cell immortality in most human malignancies, making telomerase an attractive therapeutic target. Indeed, a telomerase inhibitor is expected to provide a therapeutic benefit in most cancers while having little side-effects. The adult stem cells that express telomerase in normal tissues divide slowly and have long telomeres, therefore they should be less impacted by telomerase inhibition than the cancer cells which divide rapidly and usually possess short telomeres.

Telomerase Related Products (51):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00268
    Telomerase-IN-1
    		Inhibitor 99.84%
    Telomerase-IN-1 is a Telomerase inhibitor with an IC50 of 0.19 μM.
    Telomerase-IN-1
  • HY-122482
    β-Rubromycin
    		Inhibitor
    β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively.
    β-Rubromycin
  • HY-126482
    Telomerase-IN-2
    		Inhibitor 99.29%
    Telomerase-IN-2 is a telomerase inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC50 of 0.89 µM. Anti-cancer activity.
    Telomerase-IN-2
  • HY-172662
    TRF1-TIN2 PPI-IN-1
    		Inhibitor 99.85%
    TRF1-TIN2 PPI-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 PPI-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM). TRF1-TIN2 PPI-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 PPI-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers.
    TRF1-TIN2 PPI-IN-1
  • HY-169518
    TERT activator-2
    		Inhibitor 99.47%
    TERT activator-2 (Compound 1030) is a telomerase reverse transcriptase (TERT) activator that can increase the expression of TERT in cells. TERT activator-2 can be used in telomere-related cell lifespan research.
    TERT activator-2
  • HY-17423E
    Abacavir hydrochloride
    		Inhibitor
    Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir hydrochloride
  • HY-17423B
    Abacavir monosulfate
    		Inhibitor 98.86%
    Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir monosulfate
  • HY-E70576
    TelN Protelomerase
    TelN Protelomerase is a prokaryotic telomerase of bacteriophage N15. TelN Protelomerase is an enzyme with cleaving-joining activity, which is required for the formation of linear prophage DNA with closed ends in lysogenic bacteria. TelN Protelomerase cleaves both DNA strands and joins the resulting ends to form covalently closed hairpin structures.
    TelN Protelomerase
  • HY-204056
    Telomerase-IN-8
    		Inhibitor
    Telomerase-IN-8 is an orally active telomerase inhibitor, with an IC50 value of 0.98 μM. Telomerase-IN-8 exhibits potent antiproliferative activity against multiple tumor cell lines, including PC3, Bcap-37, MGC-803 and HepG2. Telomerase-IN-8 demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft mice. Telomerase-IN-8 can be used for the study of telomerase-targeted anticancer.
    Telomerase-IN-8
  • HY-163914
    Telomerase-IN-7
    		Inhibitor
    Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC50 of 0.03 μM.
    Telomerase-IN-7
  • HY-17423AR
    Abacavir sulfate (Standard)
    		Inhibitor
    Abacavir (sulfate) (Standard) is the analytical standard of Abacavir (sulfate). This product is intended for research and analytical applications. Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir sulfate (Standard)
  • HY-163137
    Telomerase-IN-6
    		Inhibitor
    Telomerase-IN-6（6f）is a telomerase inhibitor with antitumor activity.
    Telomerase-IN-6
  • HY-179155
    PI3K/mTOR-IN-19
    		Inhibitor
    PI3K/mTOR-IN-19 is an orally active, potent, selective PI3K (IC50 = 4.23 nM) and mTOR (IC50 = 2.3 nM) inhibitor. PI3K/mTOR-IN-19 significantly inhibits Eca109 cell viability and induces apoptosis. PI3K/mTOR-IN-19 causes G0/G1 cell cycle arrest, decreased mitochondrial membrane potential, and demonstrates marked telomerase inhibitory activity. PI3K/mTOR-IN-19 modulates the expression of key apoptotic regulators (Bcl-2, Bax, and p53) and downregulates the PI3K/Akt/mTOR signaling pathway. PI3K/mTOR-IN-19 can be used for the study of esophageal cancer.
    PI3K/mTOR-IN-19
  • HY-168890
    TRF2-IN-1
    		Inhibitor
    TRF2-IN-1 (compound F2) is a potent telomere repeat-binding factor 2 (TRF2) inhibitor. TRF2-IN-1 shows antiproliferative activity. TRF2-IN-1 induces apoptosis. TRF2-IN-1 directly bind to the TRF2TRFH domain and selectively inhibits TRF2 protein expression and telomeric localization. TRF2-IN-1 shows anticancer activity. TRF2-IN-1 has the potential for the research of osteosarcoma.
    TRF2-IN-1
  • HY-N1485R
    Cycloastragenol (Standard)
    		Activator
    Cycloastragenol (Standard) is the analytical standard of Cycloastragenol. This product is intended for research and analytical applications. Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties.
    Cycloastragenol (Standard)
  • HY-W250161
    7-Deaza-2′-deoxyguanosine 5′-triphosphate
    		Inhibitor
    7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a telomerase inhibitor (IC50: 11 μM).
    7-Deaza-2′-deoxyguanosine 5′-triphosphate
  • HY-122092
    FJ-5002
    		Inhibitor
    FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer.
    FJ-5002
  • HY-174352
    TERT ligand-1
    		Inhibitor
    TERT ligand-1 is a PROTAC target protein ligand that can be used to synthesize the PROTAC NU-PRO-1 (HY-174351). NU-PRO-1 induces TERT degradation in cancer cells.
    TERT ligand-1
  • HY-105067A
    Tertomotide hydrochloride
    Tertomotide (GV1001) hydrochloride is peptide vaccine consists a 16-aa human telomerase reverse transcriptase (hTERT) sequence. Tertomotide hydrochloride shows neuroprotective. Tertomotide hydrochloride has the potential for the research of Alzheimer's disease.
    Tertomotide hydrochloride
  • HY-148200
    L2H2-6OTD
    		Inhibitor
    L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM.
    L2H2-6OTD