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Cat. No.: HY-163914

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Telomerase-IN-7

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM.

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CAS No.: 444320-44-9
Formula: C₂₄H₃₀N₂O₆
Molecular Weight:442.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Telomerase-IN-7 Chemical Structure

CAS No.: 444320-44-9

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Sample (0.1mg)

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	26.892 μM Compound: 9	Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
GES1	IC₅₀	>1000 μM Compound: 9	Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
HL-60	IC₅₀	155.651 μM Compound: 9	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]

Chemical Information

CAS No. 444320-44-9
Molecular Weight 442.50
Formula C₂₄H₃₀N₂O₆
SMILES

O=C(C(/C1=C/C2=CC=C(C=C2)OCC(NC(C)C)=O)=C(C)N(CC3OCCC3)C1=O)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zuo H, et al. Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity[J]. ACS Medicinal Chemistry Letters, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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