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Cat. No.: HY-148200

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L2H2-6OTD

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM.

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CAS No.: 1016263-75-4
화학식: C₃₀H₃₀N₁₀O₈
분자량:658.62

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

L2H2-6OTD Chemical Structure

CAS No.: 1016263-75-4

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Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM^[1].

All ADC Payloads Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.4 μM Compound: fig. 9, R1C3-1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	10.1039/C0MD00241K
KB 3-1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay	[PMID: 20409709]
KB-V1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay	[PMID: 20409709]

Chemical Information

CAS No. 1016263-75-4
분자량 658.62
화학식 C₃₀H₃₀N₁₀O₈
SMILES

NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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L2H2-6OTD

All ADC Payloads Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

L2H2-6OTD Related Classifications

HY-148200 Related Classifications