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Cat. No.: HY-148200

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L2H2-6OTD

Name: L2H2-6OTD
Brand: MedChemExpress
SKU: HY-148200
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM.

For research use only. We do not sell to patients.

CAS No.: 1016263-75-4
Formula: C₃₀H₃₀N₁₀O₈
Molecular Weight:658.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

L2H2-6OTD Chemical Structure

CAS No.: 1016263-75-4

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.4 μM Compound: fig. 9, R1C3-1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	10.1039/C0MD00241K
KB 3-1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay	[PMID: 20409709]
KB-V1	IC₅₀	>10 μM Compound: 6c	Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay	[PMID: 20409709]

Chemical Information

CAS No. 1016263-75-4
Molecular Weight 658.62
Formula C₃₀H₃₀N₁₀O₈
SMILES

NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Mol Cancer Ther

2026 Jul 15:10.1158/1535-7163.MCT-26-0182. PMID: 42456172

Protocols

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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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L2H2-6OTD

Publications Citing Use of MedChemExpress (MCE) L2H2-6OTD

All ADC Payloads Isoforms