2. Cell Cycle/DNA Damage
  3. Telomerase
  4. L2H2-6OTD formic

L2H2-6OTD formic contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD formic has telomerase inhibitory activity with an IC50 value of 15 nM.

For research use only. We do not sell to patients.

L2H2-6OTD formic Chemical Structure

L2H2-6OTD formic Chemical Structure

Size Price Stock Quantity
1 mg USD 980 In-stock
5 mg USD 2800 In-stock
10 mg USD 4500 In-stock
25 mg USD 8300 In-stock
50 mg USD 13300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

L2H2-6OTD formic contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD formic has telomerase inhibitory activity with an IC50 value of 15 nM.

Molecular Weight

704.65

Formula

C31H32N10O10
Appearance

Solid

Color

White to off-white

SMILES

O=CO.NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (141.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4191 mL 7.0957 mL 14.1914 mL
5 mM 0.2838 mL 1.4191 mL 2.8383 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4191 mL 7.0957 mL 14.1914 mL 35.4786 mL
5 mM 0.2838 mL 1.4191 mL 2.8383 mL 7.0957 mL
10 mM 0.1419 mL 0.7096 mL 1.4191 mL 3.5479 mL
15 mM 0.0946 mL 0.4730 mL 0.9461 mL 2.3652 mL
20 mM 0.0710 mL 0.3548 mL 0.7096 mL 1.7739 mL
25 mM 0.0568 mL 0.2838 mL 0.5677 mL 1.4191 mL
30 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1826 mL
40 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8870 mL
50 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7096 mL
60 mM 0.0237 mL 0.1183 mL 0.2365 mL 0.5913 mL
80 mM 0.0177 mL 0.0887 mL 0.1774 mL 0.4435 mL
100 mM 0.0142 mL 0.0710 mL 0.1419 mL 0.3548 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L2H2-6OTD formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L2H2-6OTDTelomeraseInhibitorinhibitorinhibit

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