Thrombin Inhibitor

Thrombin Inhibitors (159):

Cat. No.	상품명	효과	Purity

HY-18660S

Ciraparantag-d₈ tetrahydrochloride diacetate	Inhibitor
Ciraparantag-d₈ (PER977-d₈) tetrahydrochloride diacetate is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.

HY-P1636A

Hirudin (54-65) TFA	Inhibitor
Hirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.

HY-119680

AT-1459	Inhibitor
AT-1459 is a selective and orally active direct Thrombin inhibitor with a K_i value of 4.9 nM. AT-1459 exhibits excellent antithrombotic activity in both rat models of venous and arterial thrombosis. AT-1459 can be used for research on thrombosis-related diseases.

HY-P2102

BCH-2763	Inhibitor
BCH-2763 is a potent and selective Thrombin inhibitor. BCH-2763 has a very high affinity for thrombin (K_i = 0.11 nM). BCH-2763 can effectively inhibit fibrin formation, platelet aggregation, and free thrombin activity. BCH-2763 can be used for the study of thrombosis.

HY-160824

Neutrophil elastase-IN-7	Inhibitor
Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC₅₀ value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC₅₀ values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.

HY-N17623

Ainsliaeasin C	Inhibitor
Ainsliaeasin C, a 7-hydroxycoumarin derivative, is an orally active anticoagulant agent that can be found in Ainsliaea fragrans. Ainsliaeasin C exerts anticoagulant activity both in vitro and in vivo. Ainsliaeasin C can be used for the research on thrombotic disorders.

HY-114603B

Efegatran dihydrochloride	Inhibitor
Efegatran (LY 294468) dihydrochloride is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.

HY-12586

AZD6564	Inhibitor
AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC₅₀ of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC₅₀ of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats.

HY-10163S3

Dabigatran-¹³C,d₃	Inhibitor
Dabigatran-¹³C,d₃ is the ¹³C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

HY-120563

LY135305	Inhibitor
LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival.

HY-19373

RWJ-445167	Inhibitor
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-B0209S

Metolazone-d₇	Inhibitor	99.90%
Metolazone-d₇ is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

HY-116363A

(21S)-Argatroban	Inhibitor
(21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation.

HY-149396A

FXIIa-IN-1 hydrochloride	Inhibitor
FXIIa-IN-1 hydrochloride is the hydrochloride of FXIIa-IN-1 (HY-149396). FXIIa-IN-1 (Compound 22) is a Factor XIIa inhibitor (K_i^app: 97.8 nM). FXIIa-IN-1 can be used for research of thrombosis.

HY-125528

Ro 09-1679	Inhibitor
Ro 09-1679 is a thrombin inhibitor, with an IC₅₀ of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC₅₀ values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively.

HY-18660A

Ciraparantag TFA	Inhibitor
Ciraparantag (PER977) TFA is a thrombin and factor Xa inhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.

HY-170485

Thrombin inhibitor 13	Inhibitor
Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC₅₀ of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities.

HY-120491

L 722151	Inhibitor
L 722151 is a competitive inhibitor for factor XIIIa with K_i of 49 µM. L 722151 accelerates tissue plasminogen activator-catalyzed clot dissolution, and exhibits antithrombotic efficacy.

HY-174285

NAPAP	Inhibitor
NAPAP is a selective direct thrombin inhibitor. NAPAP rapidly binds to thrombin and inhibits its activity, and reduces LPS (HY-D1056)-induced brain inflammation and coagulation factor expression in vivo. NAPAP can be used in studies related to coagulation and neuroinflammation.

HY-P991991

Anti-Factor V Antibody	Inhibitor
Anti-Factor V Antibody is an anti-Factor V antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

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