Metolazone-d₇  (Synonyms: SR-720-22-d₇)

Metolazone-d₇ is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

372.88

C₁₆H₉D₇ClN₃O₃S

2714484-71-4

Solid

White to off-white

O=S(C1=CC2=C(NC(C)N(C3=C([2H])C([2H])=C([2H])C([2H])=C3C([2H])([2H])[2H])C2=O)C=C1Cl)(N)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Stern A. Metolazone, a diuretic agent. Am Heart J. 1976 Feb;91(2):262-3.  [Content Brief]

  [3]. Thompson DM. A new antihypertensive: metolazone treatment of hypertension. J Kans Med Soc. 1977 Jul;78(7):337-9, 342.  [Content Brief]