Metolazone-d7
Based on 1 Customer Validation
Metolazone-d7 is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 2714484-71-4
- Formula: C16H9D7ClN3O3S
- Molecular Weight:372.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2714484-71-4
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Unlabeled Cas 17560-51-9
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Appearance Solid
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Molecular Weight 372.88
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Formula C16H9D7ClN3O3S
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Color White to off-white
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SMILES
O=S(C1=CC2=C(NC(C)N(C3=C([2H])C([2H])=C([2H])C([2H])=C3C([2H])([2H])[2H])C2=O)C=C1Cl)(N)=O
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Synonyms
SR-720-22-d7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (268.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.67 mg/mL (1.80 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Stern A. Metolazone, a diuretic agent. Am Heart J. 1976 Feb;91(2):262-3. [Content Brief]
[3]. Thompson DM. A new antihypertensive: metolazone treatment of hypertension. J Kans Med Soc. 1977 Jul;78(7):337-9, 342. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.6818 mL | 13.4091 mL | 26.8183 mL | 67.0457 mL |
| DMSO | 5 mM | 0.5364 mL | 2.6818 mL | 5.3637 mL | 13.4091 mL |
| 10 mM | 0.2682 mL | 1.3409 mL | 2.6818 mL | 6.7046 mL | |
| 15 mM | 0.1788 mL | 0.8939 mL | 1.7879 mL | 4.4697 mL | |
| 20 mM | 0.1341 mL | 0.6705 mL | 1.3409 mL | 3.3523 mL | |
| 25 mM | 0.1073 mL | 0.5364 mL | 1.0727 mL | 2.6818 mL | |
| 30 mM | 0.0894 mL | 0.4470 mL | 0.8939 mL | 2.2349 mL | |
| 40 mM | 0.0670 mL | 0.3352 mL | 0.6705 mL | 1.6761 mL | |
| 50 mM | 0.0536 mL | 0.2682 mL | 0.5364 mL | 1.3409 mL | |
| 60 mM | 0.0447 mL | 0.2235 mL | 0.4470 mL | 1.1174 mL | |
| 80 mM | 0.0335 mL | 0.1676 mL | 0.3352 mL | 0.8381 mL | |
| 100 mM | 0.0268 mL | 0.1341 mL | 0.2682 mL | 0.6705 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Metolazone-d7 Related Classifications
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