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Cat. No.: HY-116363A

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(21S)-Argatroban

(21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation.

For research use only. We do not sell to patients.

CAS No.: 121785-72-6
Formula: C₂₃H₃₆N₆O₅S
Molecular Weight:508.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(21S)-Argatroban Chemical Structure

CAS No.: 121785-72-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

(21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	EC₅₀	0.007 μM Compound: Argatroban	Inhibition of thrombin induced platelet activation in CD-1 mouse plasma incubated for 2 mins by luminescence based assay Inhibition of thrombin induced platelet activation in CD-1 mouse plasma incubated for 2 mins by luminescence based assay	[PMID: 36462436]
Platelet	EC₅₀	0.024 μM Compound: Argatroban	Inhibition of tissue factor induced platelet activation in 76% human blood incubated for 15 mins by CD62 antibody based assay Inhibition of tissue factor induced platelet activation in 76% human blood incubated for 15 mins by CD62 antibody based assay	[PMID: 36462436]

In Vivo

(21S)-Argatroban (0.4 mg/kg, i.v., once daily for 3 consecutive days) significantly prolongs whole blood clotting time, recalcification time, prothrombin time, thrombin time and activated partial thromboplastin time and reduces platelet adhesion, aggregation in normal domestic dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Domestic dogs^[1]
Dosage:

0.4 mg/kg
Administration:

intravenous infusion, once daily for 3 consecutive days
Result:

Increased CT time from 390.8-551.8.
Increased RT time from 143.2-196.5.
Increased PT time from 5.6-9.6.
Increased TT time from 11.1-53.3.
Increased ATPP time from 20-24.5.

Chemical Information

CAS No. 121785-72-6
Molecular Weight 508.64
Formula C₂₃H₃₆N₆O₅S
SMILES

S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)C[C@H](C)CN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Honghai Song, et al. Application of 21(S) argatroban. CN101032485A. 2009-03-11

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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