2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3822):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-172583
    Neuroprotective agent 9
    Neuroprotective agent 9 (compound 7) is a neuroprotective agent. Neuroprotective agent 9 is promising for research of neuron injury such as cerebral apoplexy, cerebral injury, and neuropathic pain.
    Neuroprotective agent 9
  • HY-108289
    Sobrerol
    Sobrerol ((Rac)-NRM-331) is a monoterpene compound. Sobrerol promotes mucus clearance and improves respiratory infections. Sobrerol can be used in research on respiratory diseases.
    Sobrerol
  • HY-172097
    HL22
    HL22 is a harmaline derivative. HL22 significantly inhibits HCT116, MGC803 and MCF7 cancer cell lines, and inhibits MGC803 cell migration and monoclonal formation. The anti-cancer mechanism of HL22 is related to a variety of metabolic pathways and can be used in the study of cancer.
    HL22
  • HY-101203
    GJ103
    GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations.
    GJ103
  • HY-186169
    R-MDDMA
    R-MDDMA, 4-methylenedioxymethamphetamine (MDMA) analogue, is a 5-HT2A/5-HT2C receptor modulator. R-MDDMA shows antagonistic activity against 5-HT2A/5-HT2C with IC50 values of 642 and 137 nM, and also shows partial agonist activity with EC50 values of 24.5 and 14.4 nM, but does not activate 5-HT2B receptors. R-MDDMA promotes cortical neuron growth. R-MDDMA facilitates fear extinction learning and produces antidepressant-like effects in preclinical rodent models. R-MDDMA can be used for the researches of post-traumatic stress disorder and depression.
    R-MDDMA
  • HY-126836
    L-685487
    L-685487 is a 13-desmethyl derivative of FK506 (HY-13756). L-685487 is promising for research of immunomodulators.
    L-685487
  • HY-B0230B
    Pyrazinobutazone
    Pyrazinobutazone (Phenylbutazone piperazium) is an antipyrene derivative that possesses anti-inflammatory properties and has been associated with hypersensitivity reactions leading to agranulocytosis and liver injury.
    Pyrazinobutazone
  • HY-161757
    Anti-inflammatory agent 86
    Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research.
    Anti-inflammatory agent 86
  • HY-N16782
    Curdionolide A
    Curdionolide A is a natural sesquiterpene.
    Curdionolide A
  • HY-N17435
    Phloridzin 2''-acetate
    Phloridzin 2''-acetate is a dihydrochalcone glycoside found in the leaves of Kalmia latifolia.
    Phloridzin 2''-acetate
  • HY-N17093
    (Rac)-Kushenol Q
    (Rac)-Kushenol Q is a natural flavonoid.
    (Rac)-Kushenol Q
  • HY-118544
    Sch 24937
    Sch 24937 is an active compound.
    Sch 24937
  • HY-111983
    Etiroxate
    Etiroxate (CG-635) is a lipid lowing compound which can be used for hyperlipoproteinemia research.
    Etiroxate
  • HY-118160
    PPM-18
    		99.17%
    PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis.
    PPM-18
  • HY-N17487
    Eryngioside I
    Eryngioside I is a natural product that can be found in Trifolium pratense?L..
    Eryngioside I
  • HY-107084
    TT-62
    TT-62 is an orally active derivative of FdUMP, which is the active metabolite of 5-Fluorouracil (HY-90006). TT-62 can be used for the research of cancer.
    TT-62
  • HY-N17341
    (+)-Mornaphthoate A
    (+)-Mornaphthoate A (compound 1) is a methyl 2-naphthoate derivative that can be found in Morinda officinalis var. officinalis.
    (+)-Mornaphthoate A
  • HY-113531
    ZK 95962
    ZK 95962 is an active compound.
    ZK 95962
  • HY-114563
    LY 223592
    LY 223592 (Compound I-a) is a Gemcitabine (HY-17026) derivative. LY 223592 has the biological activity of highly selective inhibition of lung cancer cell proliferation (IC50 = 5.6 nM in A549 cells) and low cytotoxicity to normal cells. LY 223592 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC).
    LY 223592
  • HY-177762
    Pan-RAS-IN-8
    Pan-RAS-IN-8 (Page 152, third row, third from left to right) is a pan-RAS inhibitor. Pan-RAS-IN-8 blocks the binding of RAS to downstream effector molecules by forming a ternary complex, thereby inhibiting the activation of the MAPK and PI3K-AKT signaling pathways. Pan-RAS-IN-8 can be used for the research of cancer, inflammatory diseases and autoimmune diseases.
    Pan-RAS-IN-8