Anti-inflammatory agent 86
Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research.
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- Formule: C29H34N2O5S2
- Masse moléculaire:554.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Anti-inflammatory agent 86 (compound 4b) exhibits significant inhibitory activity against the adhesion of monocytes to HT-29 cells induced by TNF-α, with an IC50 value of 4.71 μM[1].
Anti-inflammatory agent 86 (5-10 μM; 4 h) significantly suppresses the expression of MCP-1 in a concentration-dependent manner. Anti-inflammatory agent 86 inhibits NF-κB activity in HT-29 cells in a dose-dependent manner[1].
Anti-inflammatory agent 86 (5-10 μM) demonstrates a notable inhibitory effect on the generation of ROS induced by TNF-α in a dose-dependent fashion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TNF-α-stimulated HT-29 cells
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Concentration:5 μM, 10 μM
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Incubation Time:Pretreatment with 1 h and then treat for 3 hours
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Result:Effectively suppressed TNF-α-induced intercellular adhesion molecule (ICAM)-1 expression in a manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Sprague-Dawley (SD) rats bearing colitis (induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS))[1].
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Dosage:30 mg/kg/day or 60 mg/kg/day (10% DMSO, 15% SBE-β-CD, and 75% saline)
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Administration:po; once daily; for 15 days
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Result:Exhibiteds a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
Chemical Information
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Masse moléculaire 554.72
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Formule C29H34N2O5S2
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SMILES
O=C(N1CCN(CCOC2=CC(OC(C3=CC=CC=C3)=CC4=O)=C4C(O)=C2)CC1)CCCCC5CCSS5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 86 Related Classifications
HY-161757 Related Classifications
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