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Cat. No.: HY-161757

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Anti-inflammatory agent 86

Anti-inflammatory agent 86 is a Chrysin (HY-14589) derivative with anti-inflammatory effects. Anti-inflammatory agent 86 inhibits monocyte adhesion to colon epithelium induced by TNF-α, with an IC₅₀ of 4.71 μM. Anti-inflammatory agent 86 has the potential for the inflammatory bowel disease (IBD) research.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₄N₂O₅S₂
Molecular Weight:554.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anti-inflammatory agent 86 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Anti-inflammatory agent 86 (compound 4b) exhibits significant inhibitory activity against the adhesion of monocytes to HT-29 cells induced by TNF-α, with an IC₅₀ value of 4.71 μM^[1].
Anti-inflammatory agent 86 (5-10 μM; 4 h) significantly suppresses the expression of MCP-1 in a concentration-dependent manner. Anti-inflammatory agent 86 inhibits NF-κB activity in HT-29 cells in a dose-dependent manner^[1].
Anti-inflammatory agent 86 (5-10 μM) demonstrates a notable inhibitory effect on the generation of ROS induced by TNF-α in a dose-dependent fashion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

TNF-α-stimulated HT-29 cells
Concentration:

5 μM, 10 μM
Incubation Time:

Pretreatment with 1 h and then treat for 3 hours
Result:

Effectively suppressed TNF-α-induced intercellular adhesion molecule (ICAM)-1 expression in a manner.

In Vivo

Anti-inflammatory agent 86 (30-60 mg/kg; po; once daily; for 15 days) demonstrates the most significant efficacy in the treatment of TNBS-induced colitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Sprague-Dawley (SD) rats bearing colitis (induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS))^[1].
Dosage:

30 mg/kg/day or 60 mg/kg/day (10% DMSO, 15% SBE-β-CD, and 75% saline)
Administration:

po; once daily; for 15 days
Result:

Exhibiteds a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.

Chemical Information

Molecular Weight 554.72
Formula C₂₉H₃₄N₂O₅S₂
SMILES

O=C(N1CCN(CCOC2=CC(OC(C3=CC=CC=C3)=CC4=O)=C4C(O)=C2)CC1)CCCCC5CCSS5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pengyu Zhao, et al. Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease. Front Chem. 2024 May 27:12:1406051. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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