2. GJ103

GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (GJ103 sodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

GJ103 Chemical Structure

GJ103 Chemical Structure

CAS No. : 1459687-89-8

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GJ103 Related Antibodies

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Description

GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].

In Vivo

GJ103 (10-30 μM; 4 days) induces ATM kinase activity in AT153LA cells with a homozygous TGA mutation and a homozygous TAA mutation[1].
GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

342.37

Formula

C16H14N4O3S
CAS No.
SMILES

OC(CSC1=NN=C(N1C2=CC=CC(OC)=C2)C3=NC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GJ1031459687-89-8GJ 103GJ-103Inhibitorinhibitorinhibit

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GJ103
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HY-101203
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