2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3823):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173531
    8-Bromo TNP-ITP tetrasodium
    8-Bromo TNP-ITP (8-Bromo TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706).
    8-Bromo TNP-ITP tetrasodium
  • HY-N6854A
    3α-Hydroxymogroside IA1
    3α-Hydroxymogroside IA1 is a mogroside derivative.
    3α-Hydroxymogroside IA1
  • HY-47874
    WAY-639729
    WAY-639729 is an active molecule.
    WAY-639729
  • HY-178721
    Lithocholic amide-C2-N(didecane)
    Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway.
    Lithocholic amide-C2-N(didecane)
  • HY-179616
    AT-9
    AT-9 is an anthraquinone-triazene derivative. AT-9 exhibits strong DNA intercalation ability. AT-9 can also interact with Topo IIA. AT-9 exhibits anticancer activity against non-small cell lung cancer and cervical cancer.
    AT-9
  • HY-N16993
    1-O-p-Coumaroyl-3-O-feruloylglycerol
    1-O-p-Coumaroyl-3-O-feruloylglycerol is a natural phenylacetylene.
    1-O-p-Coumaroyl-3-O-feruloylglycerol
  • HY-172579
    (±)15,16-DiHODE
    (±)15,16-DiHODE is a derived oxylipin of α-Linolenic acid (HY-N0728).
    (±)15,16-DiHODE
  • HY-N17859
    Avicularoside
    Avicularoside (Compound 4) is a flavonoid glycoside that can be isolated from the leaves of Nepenthes gracilis.
    Avicularoside
  • HY-D2957
    BG-Nor
    BG-Nor (NorBG) is a Benzylguanine analogue containing Norbornene (HY-W013021). BG-Nor can be converted by cell surface SNAP tags. NorBG can be used for tetrazine-linked labeling of cells via the iEDDA reaction.
    BG-Nor
  • HY-N1296
    Serratriol
    Serratriol is a natural triterpene.
    Serratriol
  • HY-P1360
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a nonimmunosuppressive cyclosporin A derivative. H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe has the potential for the research of congenital muscular dystrophy.
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
  • HY-47687
    WAY-221060
    		98.0%
    WAY-221060-A is an active molecule.
    WAY-221060
  • HY-120840
    GR 100679
    GR 100679 is an active compound.
    GR 100679
  • HY-W471938
    Antiproliferative agent-35
    Antiproliferative agent-35 (Compound 4) is an anticancer agent derivated from Esculetin (HY-N0284). Antiproliferative agent-35 inhibits the proliferation of B16 and A549 cells, with IC50s of 13.2 and 9.2 μM resspectively.
    Antiproliferative agent-35
  • HY-N19720
    Bractein
    Bractein is a natural aurone flavonoid with potential antioxidant activity. Bractein shows in vitro antileishmanial activity and inhibits promastigotes and intracellular amastigotes of Leishmania donovani. Bractein exhibits no obvious cytotoxicity against mammalian macrophages with an EC50 value > 25.0 μg/mL. Bractein can be used for the research of Leishmania.
    Bractein
  • HY-139938
    (±)11(12)-EET methyl ester
    (±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
    (±)11(12)-EET methyl ester
  • HY-N16903
    Drim-8(12)-en-6β,7α, 9α,11-tetraol
    Drim-8(12)-en-6β,7α, 9α,11-tetraol is a natural sesquiterpene.
    Drim-8(12)-en-6β,7α, 9α,11-tetraol
  • HY-19356B
    (+)-Rocaglamide
    (+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
    (+)-Rocaglamide
  • HY-105136A
    Dezaguanine
    Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research.
    Dezaguanine
  • HY-160199A
    3'-L-histidyl-AMP disodium
    3'-L-histidyl-AMP (disodium) is applicable for nucleoside modification (DNA, RNA).
    3'-L-histidyl-AMP disodium