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  4. Dezaguanine

Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research.

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Dezaguanine

Dezaguanine Chemical Structure

CAS No. : 41729-52-6

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Dezaguanine Related Antibodies

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Description

Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research[1][2].

In Vitro

Dezaguanine (0.1-150 μg/mL) inhibits virus-induced cytopathic effects in primary rabbit kidney cells, Vero cells and HeLa cells, with an IC50 range of 0.1 to 150 μg/mL against all tested viruses[1].
Dezaguanine (0.01-1.50 mM; 7 days) inhibits the growth of wild-type CHO cells, APRT-deficient CHO AAR-6a cells, and HGPRT-deficient CHO TGR-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dezaguanine Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Wild-type CHO cells, APRTase-deficient CHO AAR-6a cells, HGPRTase-deficient CHO TGR-1 cells
Concentration: 0.01 mM; 0.50 mM; 1.50 mM
Incubation Time: 7 days
Result: Inhibited growth with a minimum inhibitory concentration of 0.01 mM in wild-type CHO cells.
Inhibited growth with a minimum inhibitory concentration of 0.50 mM in APRTase-deficient CHO AAR-6a cells.
Inhibited growth with a minimum inhibitory concentration of 1.50 mM in HGPRTase-deficient CHO TGR-1 cells.
In Vivo

Dezaguanine (intravenous injection/intraperitoneal injection; single dose/5 consecutive days) exhibits an LD10 of 98 mg/kg following a single intravenous administration, and an LD10 of 112 mg/kg/day following daily intraperitoneal administration for 5 consecutive days in mice[2].
Dezaguanine (17-270 mg/kg; intravenous injection; single dose/5 consecutive days) only causes mild gastrointestinal reactions in Beagle dogs at a single intravenous dose of 270 mg/kg, whereas the 17 mg/kg dose administered intravenously for 5 consecutive days is lethal[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Beagle[2]
Dosage: 270 mg/kg (single i.v. dose); 17 mg/kg/day (5-day daily i.v. dose)
Administration: i.v. (single dose; daily; 5 consecutive days)
Result: Caused only mild emesis and anorexia, with no detectable organ toxicities via biochemical or histological evaluation (single i.v. 270 mg/kg dose).
Was lethal, with death secondary to necrotizing enteritis and myelosuppression (5-day daily i.v. 17 mg/kg dose).
Molecular Weight

150.14

Formula

C6H6N4O
CAS No.
SMILES

O=C1NC(N)=CC=2NC=NC12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dezaguanine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dezaguanine41729-52-6Drug DerivativeDrug derivativerat liver guanaseHeLa cellsVero cellsCHO cellsbreast cancer cellsprimary rabbit kidney cellsP388 lymphocytic leukemiaInhibitorinhibitorinhibit

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