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  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer 관련 제품 (434):

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-129764A
    (17E)-Prostaglandin F3α
    (17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity.
    (17E)-Prostaglandin F3α
  • HY-135383B
    (Z)-Pitavastatin calcium
    		99.63%
    (Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin Calcium (HY-B0144).
    (Z)-Pitavastatin calcium
  • HY-W783844
    (R)-Nantenine
    (R)-Nantenine ((R)-(-)-nantenine) is the levorotatory isomer of Nantenine (HY-N9141). (R)-Nantenine has high affinity and selectivity for the α1A adrenergic receptor. (R)-Nantenine can block the behavioral suppression induced by MDMA. (R)-Nantenine is mainly used for the research related to diseases caused by MDMA abuse.
    (R)-Nantenine
  • HY-184117A
    (S)-pMeO-Bz-SF
    (S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC50 of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin.
    (S)-pMeO-Bz-SF
  • HY-176792A
    (R)-ACBI-4
    (R)-ACBI-4 is an isomer of ACBI-4 (HY-176792). ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R.
    (R)-ACBI-4
  • HY-B1254A
    (-)-Altizide
    (-)-Altizide is the levorotatory enantiomer of Altizide (HY-B1254). Altizide is an orally active diuretic. Altizide can be used in studies of oedema and hypertension.
    (-)-Altizide
  • HY-135597
    N-Acetyl-5-methyl-L-tryptophan
    		98.39%
    N-Acetyl-5-methyl-L-tryptophan is a N-Acetyl-L-tryptophan analog.
    N-Acetyl-5-methyl-L-tryptophan
  • HY-161474
    Antiproliferative agent-50
    Antiproliferative agent-50 (Compd VIII-a) is an inhibitor of myeloma cell proliferation and may be used to inhibit multiple myeloma.
    Antiproliferative agent-50
  • HY-186146A
    SGI-1776-VHL-02-epimer
    SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1.
    SGI-1776-VHL-02-epimer
  • HY-14845
    Levomequitazine
    Levomequitazine (Compound V0114) ((S)-Mequitazine), the levorotatory enantiomer of Mequitazine (HY-B2168), is an orally active, inverse H4 receptor agonist (IC50s: 94 nM (hM2), 17 nM (hM3)). Levomequitazine strongly binds to human histamine H4 receptor. Levomequitazine antagonizes the activating action induced by histamine on H4 receptor. Levomequitazine induces a powerful and statistically significant anti-inflammatory effect. Levomequitazine can be used for research on inflammatory diseases.
    Levomequitazine
  • HY-141551B
    (R)-GNE-274
    (R)-GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader).
    (R)-GNE-274
  • HY-149053A
    (S)-OY-101
    (S)-OY-101 is an isomer of OY-101 (HY-149053).
    (S)-OY-101
  • HY-W699829
    (3R,5R)-Rosuvastatin Lactone-d6
    (3R,5R)-Rosuvastatin Lactone-d6 is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
    (3R,5R)-Rosuvastatin Lactone-d<sub>6</sub>
  • HY-117806
    TSR-011-isomer
    TSR-011-isomer is an isomer of Belizatinib (HY-17603), a ALK inhibitor with an IC50 of 6 nM. TSR-011-isomer acts as a substrate for metabolic hydrolysis and NADPH-dependent metabolism. TSR-011-isomer undergoes enzymatic hydrolysis in mouse plasma and NADPH-dependent metabolism in mouse liver microsomes, thereby supporting clearance processes. TSR-011-isomer can be used in studies related to ALK-driven cancers.
    TSR-011-isomer
  • HY-163825A
    (E)-RNB-61
    (E)-RNB-61 is the E configuration of RNB-61 (HY-163825). RNB-61 is an orally active cannabinoid CB2 receptor (CB2R) agonist with a Ki range of 0.13 nM to 1.81 nM. RNB-61 has renal protective and/or anti-fibrotic effects.
    (E)-RNB-61
  • HY-W012732S2
    Isoquinoline-15N
    Isoquinoline-15N is the 15N-labeled Isoquinoline (HY-W012732). Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities.
    Isoquinoline-<sup>15</sup>N
  • HY-175402
    (S)-5-Hydroxyequol
    (S)-5-Hydroxyequol is a (S)-stereochemistry of 5-Hydroxyequol. (S)-5-Hydroxyequol can be used for research on oxidative damage, fungal infections, inflammation, and immunosuppression.
    (S)-5-Hydroxyequol
  • HY-14948A
    (R)-Carisbamate
    		99.83%
    (R)-Carisbamate ((R)-RWJ-333369) is the R-Enantiomer of Carisbamate (HY-14948). Carisbamate is an orally active neuromodulator.
    (R)-Carisbamate
  • HY-107608A
    5(S),12(S)-Leukotriene B4
    5(S),12(S)-Leukotriene B4 (5(S),12(S)-LTB4; 5(S),12(S)-DiHETE) is a stereochemical isomer of LTB4 (HY-107608).
    5(S),12(S)-Leukotriene B4
  • HY-186079A
    (S)-Deethyl-emvistegrast
    (S)-Deethyl-emvistegrast is the S-enantiomer of Deethyl-emvistegrast (HY-186079). Deethyl-emvistegrast is a quinoline derivative and also a α4β7 integrin inhibitor. It acts as the hydrolysis product of Emvistegrast (HY-177080). Deethyl-emvistegrast modulates inflammatory pathways and can be used in research related to inflammatory bowel diseases (Crohn's disease and ulcerative colitis).
    (S)-Deethyl-emvistegrast