(S)-pMeO-Bz-SF 

(S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC₅₀ of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin^[1].

(S)-pMeO-Bz-SF (1 h) is a weak inhibitor of α-chymotrypsin, displaying significantly less inhibitory activity than the (R)-enantiomer ((R)-pMeO-Bz-SF) (HY-184117B) at a concentration of 1.25 μM^[1].
(S)-pMeO-Bz-SF inhibits α-chymotrypsin with an IC₅₀ of 2965 nM, which is 29-fold less potent than the (R)-enantiomer^[1].
(S)-pMeO-Bz-SF binds to α-chymotrypsin with similar calculated affinity to the (R)-enantiomer but is poorly positioned in the active site, consistent with its significantly lower inhibitory potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

293.31

C₁₄H₁₂FNO₃S

3117686-58-2

COC1=CC=C(C=C1)[S@](=O)(F)=NC(C2=CC=CC=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Streefkerk D, et al. Chiral sulfonimidoyl fluorides display potent stereoselective inhibition of chymotrypsin. Cell Reports Physical Science. 2026; 7.