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Cat. No.: HY-184117A

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(S)-pMeO-Bz-SF

(S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC₅₀ of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin.

For research use only. We do not sell to patients.

CAS No.: 3117686-58-2
Formula: C₁₄H₁₂FNO₃S
Molecular Weight:293.31

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Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-pMeO-Bz-SF Chemical Structure

CAS No.: 3117686-58-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
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Biological Activity

Description

In Vitro

(S)-pMeO-Bz-SF (1 h) is a weak inhibitor of α-chymotrypsin, displaying significantly less inhibitory activity than the (R)-enantiomer ((R)-pMeO-Bz-SF) (HY-184117B) at a concentration of 1.25 μM^[1].
(S)-pMeO-Bz-SF inhibits α-chymotrypsin with an IC₅₀ of 2965 nM, which is 29-fold less potent than the (R)-enantiomer^[1].
(S)-pMeO-Bz-SF binds to α-chymotrypsin with similar calculated affinity to the (R)-enantiomer but is poorly positioned in the active site, consistent with its significantly lower inhibitory potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3117686-58-2
Molecular Weight 293.31
Formula C₁₄H₁₂FNO₃S
SMILES

COC1=CC=C(C=C1)[S@](=O)(F)=NC(C2=CC=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Streefkerk D, et al. Chiral sulfonimidoyl fluorides display potent stereoselective inhibition of chymotrypsin. Cell Reports Physical Science. 2026; 7.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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