(S)-pMeO-Bz-SF
(S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC50 of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin.
For research use only. We do not sell to patients.
- CAS No.: 3117686-58-2
- Formula: C14H12FNO3S
- Molecular Weight:293.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(S)-pMeO-Bz-SF (1 h) is a weak inhibitor of α-chymotrypsin, displaying significantly less inhibitory activity than the (R)-enantiomer ((R)-pMeO-Bz-SF) (HY-184117B) at a concentration of 1.25 μM[1].
(S)-pMeO-Bz-SF inhibits α-chymotrypsin with an IC50 of 2965 nM, which is 29-fold less potent than the (R)-enantiomer[1].
(S)-pMeO-Bz-SF binds to α-chymotrypsin with similar calculated affinity to the (R)-enantiomer but is poorly positioned in the active site, consistent with its significantly lower inhibitory potency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3117686-58-2
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Molecular Weight 293.31
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Formula C14H12FNO3S
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SMILES
COC1=CC=C(C=C1)[S@](=O)(F)=NC(C2=CC=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-pMeO-Bz-SF Related Classifications
HY-184117A Related Classifications
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