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Cat. No.: HY-184117B

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(R)-pMeO-Bz-SF

(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC₅₀ of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.

For research use only. We do not sell to patients.

CAS No.: 3098808-75-1
Formula: C₁₄H₁₂FNO₃S
Molecular Weight:293.31

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Please store the product under the recommended conditions in the Certificate of Analysis.

(R)-pMeO-Bz-SF Chemical Structure

CAS No.: 3098808-75-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
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Biological Activity

Description

In Vitro

(R)-pMeO-Bz-SF (1 h) potently inhibits α-chymotrypsin activity in a UV-visible progression assay, completely suppressing enzyme activity at 12.5 μM and showing strong inhibition at 1.25 μM^[1].
(R)-pMeO-Bz-SF potently inhibits α-chymotrypsin with an IC₅₀ of 101 nM, which is 29-fold more potent than its (S)-enantiomer and over 11-fold more potent than PMSF (HY-B0496)^[1].
(R)-pMeO-Bz-SF binds favorably in α-chymotrypsin's S1 binding pocket, positioning the active site Ser195 residue for covalent modification, which correlates with its potent inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3098808-75-1
Molecular Weight 293.31
Formula C₁₄H₁₂FNO₃S
SMILES

COC1=CC=C(C=C1)[S@@](=O)(F)=NC(C2=CC=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Streefkerk D, et al. Chiral sulfonimidoyl fluorides display potent stereoselective inhibition of chymotrypsin. Cell Reports Physical Science. 2026; 7.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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