(R)-pMeO-Bz-SF
(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC50 of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.
For research use only. We do not sell to patients.
- CAS No.: 3098808-75-1
- Formula: C14H12FNO3S
- Molecular Weight:293.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(R)-pMeO-Bz-SF (1 h) potently inhibits α-chymotrypsin activity in a UV-visible progression assay, completely suppressing enzyme activity at 12.5 μM and showing strong inhibition at 1.25 μM[1].
(R)-pMeO-Bz-SF potently inhibits α-chymotrypsin with an IC50 of 101 nM, which is 29-fold more potent than its (S)-enantiomer and over 11-fold more potent than PMSF (HY-B0496)[1].
(R)-pMeO-Bz-SF binds favorably in α-chymotrypsin's S1 binding pocket, positioning the active site Ser195 residue for covalent modification, which correlates with its potent inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3098808-75-1
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Molecular Weight 293.31
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Formula C14H12FNO3S
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SMILES
COC1=CC=C(C=C1)[S@@](=O)(F)=NC(C2=CC=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-pMeO-Bz-SF Related Classifications
HY-184117B Related Classifications
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