(R)-pMeO-Bz-SF 

(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC₅₀ of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner^[1].

(R)-pMeO-Bz-SF (1 h) potently inhibits α-chymotrypsin activity in a UV-visible progression assay, completely suppressing enzyme activity at 12.5 μM and showing strong inhibition at 1.25 μM^[1].
(R)-pMeO-Bz-SF potently inhibits α-chymotrypsin with an IC₅₀ of 101 nM, which is 29-fold more potent than its (S)-enantiomer and over 11-fold more potent than PMSF (HY-B0496)^[1].
(R)-pMeO-Bz-SF binds favorably in α-chymotrypsin's S1 binding pocket, positioning the active site Ser195 residue for covalent modification, which correlates with its potent inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

293.31

C₁₄H₁₂FNO₃S

3098808-75-1

COC1=CC=C(C=C1)[S@@](=O)(F)=NC(C2=CC=CC=C2)=O

Room temperature in continental US; may vary elsewhere.

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• [1]. Streefkerk D, et al. Chiral sulfonimidoyl fluorides display potent stereoselective inhibition of chymotrypsin. Cell Reports Physical Science. 2026; 7.