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Cat. No.: HY-186146A

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SGI-1776-VHL-02-epimer

Name: SGI-1776-VHL-02-epimer
Brand: MedChemExpress
SKU: HY-186146A
Availability: PreOrder

(Synonyms: SGI-1776-cis-VHL-02)

SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3013618-85-1
화학식: C₅₀H₆₂F₃N₉O₆S
분자량:974.14

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SGI-1776-VHL-02-epimer Chemical Structure

CAS No.: 3013618-85-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PROTACs Isoforms :

All Pim Isoforms :

In Vitro

SGI-1776-VHL-02-epimer (0.75-10 μM; 24 h) does not degrade PIM1 protein in Doxycycline (HY-N0565)-inducible PIM1-expressing PC3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Doxycycline-inducible PIM1-expressing PC3 (PC3-dox-PIM1) cells
Concentration:

0.75, 1.5, 3.75, 6.25, 10 μM
Incubation Time:

24 h
Result:

Did not reduce PIM1 protein levels at any of the tested concentrations.

Chemical Information

CAS No. 3013618-85-1
분자량 974.14
화학식 C₅₀H₆₂F₃N₉O₆S
SMILES

O=C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCC(N(CC4)CCC4CNC5=NN6C(C7=CC(OC(F)(F)F)=CC=C7)=CN=C6C=C5)=O)=O
Synonyms

SGI-1776-cis-VHL-02
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Torres-Ayuso P, et al. PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer. Cell Chem Biol. 2024;31(2):326-337.e11. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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SGI-1776-VHL-02-epimer

All PROTACs Isoforms

All Pim Isoforms