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Cat. No.: HY-186146A

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SGI-1776-VHL-02-epimer

(Synonyms: SGI-1776-cis-VHL-02)

SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1.

For research use only. We do not sell to patients.

CAS No.: 3013618-85-1
Formula: C₅₀H₆₂F₃N₉O₆S
Molecular Weight:974.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SGI-1776-VHL-02-epimer Chemical Structure

CAS No.: 3013618-85-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Pim Isoforms :

In Vitro

SGI-1776-VHL-02-epimer (0.75-10 μM; 24 h) does not degrade PIM1 protein in Doxycycline (HY-N0565)-inducible PIM1-expressing PC3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Doxycycline-inducible PIM1-expressing PC3 (PC3-dox-PIM1) cells
Concentration:

0.75, 1.5, 3.75, 6.25, 10 μM
Incubation Time:

24 h
Result:

Did not reduce PIM1 protein levels at any of the tested concentrations.

Chemical Information

CAS No. 3013618-85-1
Molecular Weight 974.14
Formula C₅₀H₆₂F₃N₉O₆S
SMILES

O=C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCC(N(CC4)CCC4CNC5=NN6C(C7=CC(OC(F)(F)F)=CC=C7)=CN=C6C=C5)=O)=O
Synonyms

SGI-1776-cis-VHL-02
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Torres-Ayuso P, et al. PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer. Cell Chem Biol. 2024;31(2):326-337.e11. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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