3013618-85-1
3013618-85-1
Chemical Structure
SGI-1776-VHL-02-epimer
Synonym(s): SGI-1776-cis-VHL-02
- CAS. Nr.: 3013618-85-1
- Formula:C50H62F3N9O6S
- Molecular Weight:974.14
InChIKey: JTRQRCVYTIRJFM-WIQKRSONSA-N
SMILES: O=C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCC(N(CC4)CCC4CNC5=NN6C(C7=CC(OC(F)(F)F)=CC=C7)=CN=C6C=C5)=O)=O
Biological Activity: SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1[1].
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SGI-1776-VHL-02-epimer | SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1. | |||||||||||||||||||||
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