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Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (434):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124281A
    9(S)-PAHSA
    9(S)-PAHSA is a S-enantiomer of 9-PAHSA. 9-PAHSA is an orally available anti-inflammatory lipid that lowers blood sugar and reduces inflammation.
    9(S)-PAHSA
  • HY-N7801
    (±)5-HEPE
    (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
    (±)5-HEPE
  • HY-115408
    9(R)-HETE
    9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    9(R)-HETE
  • HY-W747563
    11-trans Leukotriene D4
    11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
    11-trans Leukotriene D4
  • HY-100187S
    (Rac)-[6]-Gingerol-13C,d3
    (Rac)-[6]-Gingerol-13C,d3 ((±)-[6]-Gingerol-13C,d3) is the deuterium and 13C-labeled (Rac)-[6]-Gingerol (HY-100187). (Rac)-[6]-Gingerol is a natural product. (Rac)-[6]-Gingerol can be isolated from rhizomes of Z. officinale. (Rac)-[6]-Gingerol shows moderate anticancer activity against lung cancer, ovarian cancer, melanoma, and colon cancer.
    (Rac)-[6]-Gingerol-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0317DR
    (R)-Amlodipine (Standard)
    (R)-Amlodipine (Standard) is the analytical standard of (R)-Amlodipine. This product is intended for research and analytical applications. (R)-Amlodipine is the R-Enantiomer of Amlodipine (HY-B0317 )
    (R)-Amlodipine (Standard)
  • HY-184117B
    (R)-pMeO-Bz-SF
    (R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC50 of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.
    (R)-pMeO-Bz-SF
  • HY-182317
    (+)-Mosnodenvir
    (+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.
    (+)-Mosnodenvir
  • HY-116363A
    (21S)-Argatroban
    (21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation.
    (21S)-Argatroban
  • HY-W726667A
    (R)-(-)-Citramalic acid lithium
    (R)-(-)-Citramalic acid ((R)-Citramalate) lithium, a lithium salt of Citramalic acid, is the R enantiomer of Citramalic acid lithium. (R)-(-)-Citramalic acid lithium is involved in the metabolism of glutamate through the methylaspartate pathway. (R)-(-)-Citramalic acid lithium is promising for research of neurological disorders.
    (R)-(-)-Citramalic acid lithium
  • HY-155953
    6-epi-COTC
    6-epi-COTC is a diastereoisomer of Streptomyces metabolite with a anti-cancer activitie.
    6-epi-COTC
  • HY-137674A
    isoGTP sodium
    isoGTP (Isoguanosine-5'-O-triphosphate) sodium is an isomer of guanosine 5'-triphosphate and a phosphorylated form of Crotonoside (HY-N0071). isoGTP sodium inhibits transcription and induces T to C mutations in a reverse transcriptase assay. isoGTP sodium is promising for research of substrate specificity of phosphofructokinase and mutT homolog 1 (MTH1).
    isoGTP sodium
  • HY-19471
    (rac)-ZK-304709
    (rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET.
    (rac)-ZK-304709
  • HY-106841A
    (S)-Draflazine
    (S)-Draflazine ((-)-Draflazine) is the (S)-configuration of Draflazine (HY-106841). (S)-Draflazine is a potent blocker of nucleoside transport.
    (S)-Draflazine
  • HY-137258A
    (R)-N-3-Benzylnirvanol
    (R)-N-3-Benzylnirvanol is the R-isomer of (±)-N-3-Benzylnirvanol (HY-137258). (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively.
    (R)-N-3-Benzylnirvanol
  • HY-15322A
    (rel)-PRT062607
    (rel)-PRT062607 ((rel)-P505-15) is the relative configuration of PRT062607 (HY-15322). PRT062607 is a highly selective inhibitor of Syk kinase, with an IC50 value of 1-2 nM, and is more than 80 times less potent against Fgr, Lyn, FAK, Pyk2, and Zap70.
    (rel)-PRT062607
  • HY-133022R
    trans-2-Undecenoic acid (Standard)
    trans-2-Undecenoic acid (Standard) is the analytical standard of trans-2-Undecenoic acid. This product is intended for research and analytical applications. trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O[1].
    trans-2-Undecenoic acid (Standard)
  • HY-156717
    RE-33
    RE-33 is an analgesic compound. RE-33 has blood brain barrier penetration ability.
    RE-33
  • HY-N17724
    Cimicifugic acid N
    Cimicifugic acid N is the cis-isomer of Cimicifugic acid G, can be found in the aerial parts of Cimicifuga simplex and Cimicifuga japonica.
    Cimicifugic acid N
  • HY-120912A
    (E/Z)-Gingerenone A
    (E/Z)-Gingerenone A (Compound 42) is a diarylheptanoid compound. (E/Z)-Gingerenone A is isolated from the rhizomes of Zingiber officinale Rosc.
    (E/Z)-Gingerenone A