(+)-Mosnodenvir
(+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.
For research use only. We do not sell to patients.
- CAS No.: 2043343-94-6
- Formula: C26H22ClF3N2O6S
- Molecular Weight:582.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
2.9 μM
Compound: 9A, enantiomer 1
|
Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay
Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay
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[PMID: 28105266] |
Chemical Information
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CAS No. 2043343-94-6
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Molecular Weight 582.98
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Formula C26H22ClF3N2O6S
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SMILES
CS(C1=CC(OC)=CC(NC(C2=C(C=C(C=C2)Cl)OC)C(C(C3=C4)=CNC3=CC=C4OC(F)(F)F)=O)=C1)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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