2. Others Anti-infection
  3. Drug Isomer Dengue Virus
  4. (+)-Mosnodenvir

(+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.

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(+)-Mosnodenvir

(+)-Mosnodenvir Chemical Structure

CAS No. : 2043343-94-6

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Other Forms of (+)-Mosnodenvir:

(+)-Mosnodenvir Related Antibodies

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Description

(+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates[1].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
2.9 μM
Compound: 9A, enantiomer 1
Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay
Cytotoxicity against African green monkey Vero cells infected with eGPF-labeled DENV2 16681 assessed as reduction in cell viability measured after 3 days by ATPlite assay
[PMID: 28105266]
Molecular Weight

582.98

Formula

C26H22ClF3N2O6S
CAS No.
SMILES

CS(C1=CC(OC)=CC(NC(C2=C(C=C(C=C2)Cl)OC)C(C(C3=C4)=CNC3=CC=C4OC(F)(F)F)=O)=C1)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(+)-Mosnodenvir Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Mosnodenvir2043343-94-6Drug IsomerDengue VirusDENVDENV-2 genotype IIdengue feverNS4Bdengue virusDENV-3 genotype VNS3/NS2Bnon-human primatesVeroE6 cellsDENV-2 CNR_25679 strainDENV-2 genotype IVInhibitorinhibitorinhibit

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