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  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (432):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-50707
    (Rac)-TTA-P2
    		98.69%
    (Rac)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease.
    (Rac)-TTA-P2
  • HY-113545A
    (±)9-HODE
    		99.02%
    (±)9-HODE is a racemate of 9-HODE. 9-HODE is a oxidized derivatives of Linoleic acid (HY-N0729).
    (±)9-HODE
  • HY-139534A
    (S)-ARI-1
    		Control 99.80%
    (S)-ARI-1 is an S-enantiomer of ARI-1. ARI-1 is a ROR1 inhibitor and apoptosis inducer, used in NSCLC research.
    (S)-ARI-1
  • HY-157941A
    (R,R)-ART0380
    		99.06%
    (R,R)-ART0380 (Compound 38) is the enantiomer of ART0380 (HY-157941). ART0380 is a potent and selective ATR inhibitor. ART0380 can be used in studies of advanced or metastatic solid tumors.
    (R,R)-ART0380
  • HY-100013B1
    (1S,2S)-2-PCCA hydrochloride
    		99.65%
    (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.
    (1S,2S)-2-PCCA hydrochloride
  • HY-12093A
    (R)-MMP408
    		99.91%
    (R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is an orally active MMP-12 inhibitor (IC50=2.0 nM for hMMP-12) that effectively interferes with the epithelial-mesenchymal transition (EMT) process. MMP408 significantly upregulates the expression of E-cadherin in nasal epithelial cells, while inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin and fibronectin, thereby reversing the EMT phenotype. MMP408 is used in studies of airway remodeling-related diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD) and asthma.
    (R)-MMP408
  • HY-131408
    L-Allooctopine
    		99.60%
    L-Allooctopine is a competitive inhibitor of D-octopine.
    L-Allooctopine
  • HY-E70239B
    (S)-2-Methylbutyryl-CoA sodium
    (S)-2-Methylbutyryl-CoA sodium is a S-enantiomer of 2-Methylbutyryl-CoA (HY-E70239). 2-Methylbutyryl-CoA is an intermediate of isoleucine metabolism.
    (S)-2-Methylbutyryl-CoA sodium
  • HY-100540C
    Golgicide A-1
    		Control 99.94%
    Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.
    Golgicide A-1
  • HY-162495A
    (S)-IDOR-1117-2520
    		99.47%
    (S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520 (HY-162495). IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation.
    (S)-IDOR-1117-2520
  • HY-139612A
    (S)-Opnurasib
    		99.32%
    (S)-Opnurasib ((S)-JDQ-443; (S)-NVP-JDQ443) is an isomer of Opnurasib (HY-139612). Opnurasib is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity.
    (S)-Opnurasib
  • HY-76542B
    (R)-Vitamin D2
    		Control 98.67%
    (R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
    (R)-Vitamin D2
  • HY-136453A
    CR-1-30-B
    		99.92%
    CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
    CR-1-30-B
  • HY-13636A
    Fulvestrant (S enantiomer)
    Fulvestrant (ICI 182780; ZD 9238) S enantiomer is the S-enantiomer of Fulvestrant (HY-13636), a potent estrogen receptor inhibitor. Fulvestrant binds to and blocks the estrogen receptor, promotes its degradation, and thereby inhibits receptor dimerization, nucleocytoplasmic shuttling and transcriptional activity. Fulvestrant effectively blocks estrogen signaling, MAPK pathway activation and ER-regulated protein expression. Fulvestrant induces apoptosis, inhibits the proliferation of breast cancer and prolactinoma cells, and reduces the mineralization level, alkaline phosphatase activity and osteocalcin expression of preosteoblasts. Prenatal exposure to Fulvestrant impairs ovarian follicular development and causes ovarian structural damage. Fulvestrant has been widely used in studies related to breast cancer, prolactinoma and other conditions.
    Fulvestrant (S enantiomer)
  • HY-15427A
    GDC-0834 Racemate
    		98.04%
    GDC-0834 Racemate is the racemic form of GDC-0834 (HY-15427). GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA).
    GDC-0834 Racemate
  • HY-132809B
    (Rac)-Baxdrostat
    		Inhibitor 98.24%
    (Rac)-Baxdrostat is the isomer of Baxdrostat (HY-132809), and can be used as an experimental control. Baxdrostat is a aldosterone synthase inhibitor.
    (Rac)-Baxdrostat
  • HY-W112166
    (E/Z)-4,4'-Dicyanostilbene
    		98.34%
    (E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC50 of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).
    (E/Z)-4,4'-Dicyanostilbene
  • HY-12567A
    (R)-ML375
    		98.19%
    (R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 (HY-12567). (R)-ML375 is devoid of M5 mAChR activity (hM5, IC50>30 μM).
    (R)-ML375
  • HY-124434A
    (±)-Mesembrenone
    		99.62%
    (±)-Mesembrenone is a mixture of two enantiomers of Mesembrenone (HY-124434). Mesembrenone is an alkaloid compound. (±)-Mesembrenone can be isolated from Sceletium tortuosum.
    (±)-Mesembrenone
  • HY-N0287A
    Prolycopene
    Prolycopene is a stereoisomer of Lycopene (HY-N0287) and pigment. Prolycopene can be isolated from tomatoes.
    Prolycopene