1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. GDC-0834 Racemate

GDC-0834 Racemate 

Cat. No.: HY-15427A Purity: 95.47%
Handling Instructions

GDC-0834 Racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively.

For research use only. We do not sell to patients.

GDC-0834 Racemate Chemical Structure

GDC-0834 Racemate Chemical Structure

CAS No. : 1133432-46-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 284 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 322 In-stock
Estimated Time of Arrival: December 31
50 mg USD 871 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of GDC-0834 Racemate:

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Description

GDC-0834 Racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively. IC50 value: 5.9 nM/6.4 nM(biochemical/cellular assay) [1] Target: BTK in vitro: GDC-0834 inhibited BTK with an in vitro IC(50) of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC(50) of 1.1 and 5.6 μM in mouse and rat, respectively [1]. in vivo: Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49 mg/mL (82.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6758 mL 8.3789 mL 16.7577 mL
5 mM 0.3352 mL 1.6758 mL 3.3515 mL
10 mM 0.1676 mL 0.8379 mL 1.6758 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

596.74

Formula

C₃₃H₃₆N₆O₃S

CAS No.

1133432-46-8

SMILES

O=C(C1=CC(CCCC2)=C2S1)NC3=CC=CC(C(N=C4NC5=CC=C(C6N(C)CCN(C)C6=O)C=C5)=CN(C)C4=O)=C3C

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GDC-0834 Racemate
Cat. No.:
HY-15427A
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GDC-0834 Racemate

Cat. No.: HY-15427A