GDC-0834 (S-enantiomer)

Cat. No.: HY-15427B: Ficha de datos
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GDC-0834 (S-enantiomer) is the S-enantiomer of GDC-0834. GDC-0834 is a potent and selective BTK inhibitor.

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GDC-0834 (S-enantiomer) Estructura química

No. CAS : 1133432-50-4

Tamaño	Precio	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution		Pide un presupuesto y un plazo de entrega
Solution
10 mM * 1 mL in DMSO		Pide un presupuesto y un plazo de entrega
Solid
5 mg		Pide un presupuesto y un plazo de entrega
10 mg		Pide un presupuesto y un plazo de entrega
25 mg		Pide un presupuesto y un plazo de entrega
50 mg		Pide un presupuesto y un plazo de entrega
100 mg		Pide un presupuesto y un plazo de entrega

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This product is a controlled substance and not for sale in your territory.

Other Forms of GDC-0834 (S-enantiomer):

GDC-0834 In-stock
GDC-0834 Racemate Obtener un presupuesto

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Referencias
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Descripciòn

GDC-0834 (S-enantiomer) is the S-enantiomer of GDC-0834. GDC-0834 is a potent and selective BTK inhibitor.

Peso molecular

596.74

Fòrmula

C₃₃H₃₆N₆O₃S

No. CAS

1133432-50-4

Appearance

Solid

Color

Brown to reddish brown

SMILES

CC1=C(C(N=C2NC3=CC=C([C@@H]4N(C)CCN(C)C4=O)C=C3)=CN(C)C2=O)C=CC=C1NC(C5=CC6=C(CCCC6)S5)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (167.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6758 mL	8.3789 mL	16.7577 mL
5 mM	0.3352 mL	1.6758 mL	3.3515 mL
10 mM	0.1676 mL	0.8379 mL	1.6758 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Ficha de datos (271 KB) SDS (252 KB) Instrucciones de manejo (2659 KB)

Referencias

[1]. Young WB, et al. Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6758 mL	8.3789 mL	16.7577 mL	41.8943 mL
	5 mM	0.3352 mL	1.6758 mL	3.3515 mL	8.3789 mL
	10 mM	0.1676 mL	0.8379 mL	1.6758 mL	4.1894 mL
	15 mM	0.1117 mL	0.5586 mL	1.1172 mL	2.7930 mL
	20 mM	0.0838 mL	0.4189 mL	0.8379 mL	2.0947 mL
	25 mM	0.0670 mL	0.3352 mL	0.6703 mL	1.6758 mL
	30 mM	0.0559 mL	0.2793 mL	0.5586 mL	1.3965 mL
	40 mM	0.0419 mL	0.2095 mL	0.4189 mL	1.0474 mL
	50 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8379 mL
	60 mM	0.0279 mL	0.1396 mL	0.2793 mL	0.6982 mL
	80 mM	0.0209 mL	0.1047 mL	0.2095 mL	0.5237 mL
	100 mM	0.0168 mL	0.0838 mL	0.1676 mL	0.4189 mL