1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. Evobrutinib

Evobrutinib (Synonyms: M2951; MSC2364447C)

Cat. No.: HY-101215 Purity: 98.38%
Handling Instructions

Evobrutinib (M2951) is an orally active, potent, highly selective and irreversibly covalent BTK inhibitor, with an IC50 of 8.9 nM. Evobrutinib (M2951) has potential to treat autoimmune diseases.

For research use only. We do not sell to patients.

Evobrutinib Chemical Structure

Evobrutinib Chemical Structure

CAS No. : 1415823-73-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 104 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Evobrutinib (M2951) is an orally active, potent, highly selective and irreversibly covalent BTK inhibitor, with an IC50 of 8.9 nM. Evobrutinib (M2951) has potential to treat autoimmune diseases[1].

In Vivo

Evobrutinib (0.3, 1, 3, 10, or 30 mg/kg, oral gavage, once daily) demonstrates efficacy in a rat model of rheumatoid arthritis[1].

Animal Model: Female Lewis rats with semi-established type II collagen arthritis[1].
Dosage: 0.3, 1, 3, 10, or 30 mg/kg.
Administration: Oral gavage once daily for 11 days (days 6-16).
Result: Reduced ankle histopathology scores in a dose-dependent manner, compared to vehicle.
Clinical Trial
Molecular Weight

429.51

Formula

C₂₅H₂₇N₅O₂

CAS No.

1415823-73-2

SMILES

C=CC(N1CCC(CNC2=NC=NC(N)=C2C3=CC=C(OC4=CC=CC=C4)C=C3)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (77.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3282 mL 11.6412 mL 23.2823 mL
5 mM 0.4656 mL 2.3282 mL 4.6565 mL
10 mM 0.2328 mL 1.1641 mL 2.3282 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Evobrutinib
Cat. No.:
HY-101215
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