1. Protein Tyrosine Kinase/RTK
  2. Btk

ONO-4059 (Synonyms: Tirabrutinib; GS-4059)

Cat. No.: HY-15771 Purity: 98.31%
Handling Instructions

ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.

For research use only. We do not sell to patients.

ONO-4059 Chemical Structure

ONO-4059 Chemical Structure

CAS No. : 1351636-18-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 125 In-stock
Estimated Time of Arrival: December 31
5 mg USD 114 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 336 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of ONO-4059:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. target: BTK IC:50 2.2 nM [1] In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. [1] NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities.[2] In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells. [1]

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2003 mL 11.0016 mL 22.0032 mL
5 mM 0.4401 mL 2.2003 mL 4.4006 mL
10 mM 0.2200 mL 1.1002 mL 2.2003 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

454.48

Formula

C₂₅H₂₂N₆O₃

CAS No.

1351636-18-4

SMILES

O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[[email protected]]5CN(C(C#CC)=O)CC5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ONO-4059
Cat. No.:
HY-15771
Quantity:

ONO-4059

Cat. No.: HY-15771