1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. Tirabrutinib hydrochloride

Tirabrutinib hydrochloride (Synonyms: ONO-4059 hydrochloride; GS-4059 hydrochloride)

Cat. No.: HY-15771A Purity: 98.80%
Handling Instructions

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

For research use only. We do not sell to patients.

Tirabrutinib hydrochloride Chemical Structure

Tirabrutinib hydrochloride Chemical Structure

CAS No. : 1439901-97-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tirabrutinib hydrochloride:

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Description

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

IC50 & Target

IC50: 2.2 nM (BTK)[1].

Clinical Trial
Molecular Weight

490.94

Formula

C₂₅H₂₃ClN₆O₃

CAS No.

1439901-97-9

SMILES

O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[[email protected]]5CN(C(C#CC)=O)CC5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.86 mg/mL (36.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0369 mL 10.1845 mL 20.3691 mL
5 mM 0.4074 mL 2.0369 mL 4.0738 mL
10 mM 0.2037 mL 1.0185 mL 2.0369 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.79 mg/mL (3.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.79 mg/mL (3.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.79 mg/mL (3.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.80%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

TirabrutinibONO-4059GS-4059ONO4059ONO 4059GS4059GS 4059BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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Product Name:
Tirabrutinib hydrochloride
Cat. No.:
HY-15771A
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