1. Protein Tyrosine Kinase/RTK
  2. Btk

GDC-0853 

Cat. No.: HY-19834 Purity: 99.42%
Data Sheet SDS Handling Instructions

GDC-0853 is a potent and orally BTK inhibitor.

For research use only. We do not sell to patients.
GDC-0853 Chemical Structure

GDC-0853 Chemical Structure

CAS No. : 1434048-34-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $190 In-stock
2 mg $70 In-stock
5 mg $130 In-stock
10 mg $230 In-stock
25 mg $530 In-stock
50 mg $950 In-stock
100 mg $1800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

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Description

GDC-0853 is a potent and orally BTK inhibitor. In vitro: GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02983227 Genentech, Inc. RheumatoId Arthritis November 30, 2016 Phase 2
NCT03137069 Hoffmann-La Roche Urticaria May 1, 2017 Phase 2
NCT03188783 Hoffmann-La Roche Healthy Volunteer January 24, 2017 Phase 1
NCT01991184 Genentech, Inc. Lymphocytic Leukemia, Chronic, Diffuse Large B-Cell Lymphoma December 2013 Phase 1
NCT02908100 Genentech, Inc. Systemic Lupus Erythematosus December 31, 2016 Phase 2
NCT02699710 Genentech, Inc. Healthy Volunteer September 30, 2015 Phase 1
NCT02833350 Genentech, Inc. Rheumatoid Arthritis September 9, 2016 Phase 2
NCT03174041 Genentech, Inc. Healthy Participants February 27, 2017 Phase 1
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Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.5042 mL 7.5211 mL 15.0421 mL
5 mM 0.3008 mL 1.5042 mL 3.0084 mL
10 mM 0.1504 mL 0.7521 mL 1.5042 mL
Molecular Weight

664.8

Formula

C₃₇H₄₄N₈O₄

CAS No.

1434048-34-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 23 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.42%

  • 2016-03-17 ACS会议公布 竞价

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Product Name:
GDC-0853
Cat. No.:
HY-19834
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