(1S,2S)-2-PCCA hydrochloride

Name: (1S,2S)-2-PCCA hydrochloride
Brand: MedChemExpress
SKU: HY-100013B1
Rating: 4.5 (1 reviews)

製品番号: HY-100013B1 純度: 99.65%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

(1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

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(1S,2S)-2-PCCA hydrochloride 構造式

CAS 番号 : 1609563-70-3

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 372	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 372	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$320	在庫あり	Estimated Time of Arrival: December 31
10 mg	$450	在庫あり	Estimated Time of Arrival: December 31
25 mg	$720	在庫あり	Estimated Time of Arrival: December 31
50 mg	$950	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1300	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of (1S,2S)-2-PCCA hydrochloride:

2-PCCA hydrochloride 在庫あり
(1S,2S)-2-PCCA hydrochloride (Standard) お問い合わせ

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•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

(1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

IC₅₀ & Target

GPR88 receptor^[1]

体外実験

(1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. (1R,2R)-2-PCCA is approximately 5-fold more potent than (1S,2S)-2-PCCA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

528.56

分子式

C₃₀H₃₉Cl₂N₃O

CAS 番号

1609563-70-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C([C@@H]3[C@@H](C4=CC=CC=N4)C3)=O.Cl.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (189.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8919 mL	9.4597 mL	18.9193 mL
5 mM	0.3784 mL	1.8919 mL	3.7839 mL
10 mM	0.1892 mL	0.9460 mL	1.8919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.65%

Select Batch:

データシート (272 KB) SDS (394 KB)

COA (251 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8919 mL	9.4597 mL	18.9193 mL	47.2983 mL
	5 mM	0.3784 mL	1.8919 mL	3.7839 mL	9.4597 mL
	10 mM	0.1892 mL	0.9460 mL	1.8919 mL	4.7298 mL
	15 mM	0.1261 mL	0.6306 mL	1.2613 mL	3.1532 mL
	20 mM	0.0946 mL	0.4730 mL	0.9460 mL	2.3649 mL
	25 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8919 mL
	30 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5766 mL
	40 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1825 mL
	50 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9460 mL
	60 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
	80 mM	0.0236 mL	0.1182 mL	0.2365 mL	0.5912 mL
	100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.4730 mL