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2-PCCA(hydrochloride) 

Cat. No.: HY-100013C Purity: 99.61%
Handling Instructions

2-PCCA hydrochloride is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

For research use only. We do not sell to patients.

2-PCCA(hydrochloride) Chemical Structure

2-PCCA(hydrochloride) Chemical Structure

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-PCCA(hydrochloride):

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Description

2-PCCA hydrochloride is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

IC50 & Target

EC50: 116 nM (GPR88 receptor, HEK293 cells)[1]

In Vitro

2-PCCA hydrochloride inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 116 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

In Vivo

2-PCCA (0.1-3.2 mg/kg, i.p.) decreases the locomotor activity in rats in a dose-dependent manner in rats. 2-PCCA combined with 1.0 mg/kg methamphetamine also dose-dependently reduces methamphetamine-induced hyperactivity. 2-PCCA (1-3.2 mg/kg, i.p.) alone does not produce methamphetamine-like discriminative stimulus effects, or alter the discriminative stimulus effects of methamphetamine, when studied in combination[1].

Molecular Weight

984.19

Formula

C₆₀H₇₆Cl₂N₆O₂

SMILES

[H]Cl.[H]Cl.CCCC1=CC=C(C2=CC=C(N(C[[email protected]@H](N)[[email protected]@H](C)CC)C([[email protected]@H]3[[email protected]@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.CCCC5=CC=C(C6=CC=C(N(C[[email protected]@H](N)[[email protected]@H](C)CC)C([[email protected]]7[[email protected]](C8=CC=CC=N8)C7)=O)C=C6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Animal Administration
[1]

Rats[1]
For the locomotor activity tests, rats are only used once. The test is conducted in an adjacent room from the animal colony room with similar environmental conditions (light, temperature and humidity). Before tests begin, rats are exposed to at least three days of handling by the experimenter. When only 2-PCCA (1.0 and 3.2 mg/kg) is studied, the drug is (i.p.) injected immediately before the rats are put into the test chambers and the locomotor activity is simultaneously recorded for 60 min. When 2-PCCA is studied in combination with methamphetamine, the locomotor activity is recorded for 20 min and then both drugs are simultaneously injected and the locomotor activity is recorded for 120 more min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.61%

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2-PCCA(hydrochloride)
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HY-100013C
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