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  4. 2-PCCA

2-PCCA is a racemic form of the GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

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2-PCCA

2-PCCA Chemical Structure

CAS No. : 1984859-71-3

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2-PCCA Related Antibodies

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Description

2-PCCA is a racemic form of the GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

IC50 & Target

EC50: 116 nM (GPR88 receptor, HEK293 cells)[1]
In Vitro

2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 116 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-PCCA Related Antibodies
In Vivo

2-PCCA (0.1–3.2 mg/kg, intraperitoneal injection) dose-dependently reduces kinetic activity in rats. 2-PCCA (1–3.2 mg/kg, intraperitoneal injection) does not produce a discriminative stimulus effect in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

455.63

Formula

C30H37N3O
CAS No.
SMILES

CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C(C3C(C4=CC=CC=N4)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Rats[1]
For the locomotor activity tests, rats are only used once. The test is conducted in an adjacent room from the animal colony room with similar environmental conditions (light, temperature and humidity). Before tests begin, rats are exposed to at least three days of handling by the experimenter. When only 2-PCCA (1.0 and 3.2 mg/kg) is studied, the drug is (i.p.) injected immediately before the rats are put into the test chambers and the locomotor activity is simultaneously recorded for 60 min. When 2-PCCA is studied in combination with methamphetamine, the locomotor activity is recorded for 20 min and then both drugs are simultaneously injected and the locomotor activity is recorded for 120 more min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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2-PCCA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-PCCA1984859-71-3OthersInhibitorinhibitorinhibit

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