1. Others
  2. Others
  3. (1R,2R)-2-PCCA hydrochloride

(1R,2R)-2-PCCA hydrochloride 

Cat. No.: HY-100013A1 Purity: 98.08% ee.: 99.00%
Handling Instructions

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.

For research use only. We do not sell to patients.

(1R,2R)-2-PCCA hydrochloride Chemical Structure

(1R,2R)-2-PCCA hydrochloride Chemical Structure

CAS No. : 1609563-71-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 291 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (1R,2R)-2-PCCA hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.

IC50 & Target

EC50: 3 nM (GPR88 receptor)[1], 603 nM (GPR88 receptor, in GPR88-22F cells)[2]

In Vitro

(1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay[1][2]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

528.56

Formula

C₃₀H₃₉Cl₂N₃O

CAS No.

1609563-71-4

SMILES

CCCC1=CC=C(C2=CC=C(N(C[[email protected]@H](N)[[email protected]@H](C)CC)C([[email protected]]3[[email protected]](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8919 mL 9.4597 mL 18.9193 mL
5 mM 0.3784 mL 1.8919 mL 3.7839 mL
10 mM 0.1892 mL 0.9460 mL 1.8919 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.08% ee.: 99.00%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(1R,2R)-2-PCCAOthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(1R,2R)-2-PCCA hydrochloride
Cat. No.:
HY-100013A1
Quantity:
MCE Japan Authorized Agent: