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Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer 関連製品 (432):

製品番号 製品名 製品効果 純度 構造式
  • HY-A0132
    N-Acetyl-D-glucosamine

    N-アセチル-D(+)-グルコサミン

    		99.5%
    N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.
    N-Acetyl-D-glucosamine
  • HY-103641
    (2R)-Octyl-α-hydroxyglutarate

    (2R)-Octyl-α-hydroxyglutarate

    		99.91%
    (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
    (2R)-Octyl-α-hydroxyglutarate
  • HY-103019
    Enitociclib 99.89%
    Enitociclib ((+)-BAY-1251152; (+)-VIP152) is a selective CDK9 inhibitor (IC50=3 nM) that inhibits transcriptional elongation by blocking Ser2/Ser5 phosphorylation of RNA polymerase II. Enitociclib specifically depletes key short-lived proteins such as c-MYC, MCL-1 and induces tumor cell apoptosis. Enitociclib also interferes with the production of enhancer RNAs (eRNA) and enhancer-promoter interactions, and downregulates oncogene expression at the epigenetic level. Enitociclib exerts synergistic effects with agents including Bortezomib (HY-10227), Lenalidomide (HY-A0003), Pomalidomide (HY-10984), Venetoclax (HY-15531) and Paclitaxel (HY-B0015), and even reverses paclitaxel resistance. Enitociclib serves as a vital research tool for various malignancies such as double-hit diffuse large B-cell lymphoma, multiple myeloma and pancreatic ductal adenocarcinoma.
    Enitociclib
  • HY-W011556
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate 99.93%
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate (TCFH) is a powerful coupling and derivatizing reagent for ester prodrug synthesis. N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate can be used for antitumor drugs before medicine research.
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate
  • HY-103641A
    (2S)-Octyl-α-hydroxyglutarate

    (2S)-Octyl-α-hydroxyglutarate

    		≥98.0%
    (2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.
    (2S)-Octyl-α-hydroxyglutarate
  • HY-W412861
    (S)-Linalool 99.71%
    (S)-Linalool is the enantiomer of Linalool (HY-N0368). (S)-Linalool can be used in the production of fragrances and flavorings.
    (S)-Linalool
  • HY-175751A
    (Rac)-LRK-4189
    (Rac)-LRK-4189 is the racemate of LRK-4189 (HY-175751).
    (Rac)-LRK-4189
  • HY-156794A
    Enzomenib enantiomer 98.01%
    Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib (HY-156794). Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC50=1.4 nM, Kd=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations.
    Enzomenib enantiomer
  • HY-111095B
    D-(-)-Lactic acid sodium 99.91%
    D-(-)-Lactic acid ((R)-2-Hydroxypropionic acid) sodium is an orally active, toxic optical isomer of Lactic acid (HY-B2227), mainly derived from overproduction by intestinal bacteria or exogenous intake. D-(-)-Lactic acid sodium can induce intoxication, characterized by severe metabolic acidosis accompanied by neurological symptoms.
    D-(-)-Lactic acid sodium
  • HY-111789A
    (S)-Subasumstat 98.39%
    (S)-Subasumstat is the isomer of Subasumstat (HY-111789). Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
    (S)-Subasumstat
  • HY-W012732
    Isoquinoline

    イソキノリン

    		99.58%
    Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities.
    Isoquinoline
  • HY-113381A
    (R)-2-Hydroxybutanoic acid

    (R)-2-Hydroxybutanoic acid

    		99.67%
    (R)-2-Hydroxybutanoic acid is the isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite.
    (R)-2-Hydroxybutanoic acid
  • HY-131670
    (±)9,10-DiHOME 99.90%
    (±)9,10-DiHOME is the racemate of 9,10-DiHOME.
    (±)9,10-DiHOME
  • HY-W011688
    Methyl palmitoleate

    Methyl palmitoleate

    		99.40%
    Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.
    Methyl palmitoleate
  • HY-W095705
    3-Hydroxypropionic acid (30% in water)
    3-Hydroxypropionic acid (30% in water) is a 3-hydroxy isomer of Lactic acid with varying amounts of 3,3'-Oxydipropanoic Acid. 3-Hydroxypropionic acid (30% in water) is an important building block in the synthesis of many industrially chemicals. 3-Hydroxypropionic acid (30% in water) can be produced by recombinant E. coli containing GabD4.
    3-Hydroxypropionic acid (30% in water)
  • HY-W145482
    3-O-Methyl-D-glucopyranose

    3-O-Methyl-D-glucopyranose

    		99.93%
    3-O-Methyl-D-glucopyranose is a non-metabolizable glucose analog. 3-O-Methyl-D-glucopyranose exerts a protective effect against alloxan-induced damage to rat pancreatic islet β cells. 3-O-Methyl-D-glucopyranose can be used in diabetes research.
    3-O-Methyl-D-glucopyranose
  • HY-107501
    (Rac)-1-Oleoyl lysophosphatidic acid sodium 98.0%
    (Rac)-1-Oleoyl lysophosphatidic acid ((Rac)-1-Oleoyl-sn-glycero-3-phosphate) sodium is the racemic isomer of 1-Oleoyl lysophosphatidic acid sodium (HY-107614).
    (Rac)-1-Oleoyl lysophosphatidic acid sodium
  • HY-113380
    (S)-β-Aminoisobutyric acid 99.59%
    (S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise.
    (S)-β-Aminoisobutyric acid
  • HY-N0120
    (E/Z)-Polydatin

    (E/Z)-Polydatin

    		98.13%
    (E/Z)-Polydatin ((E/Z)-Piceid) is a mixture of the E/Z configurations of Polydatin (HY-N0120A). Polydatin can be isolated from Polygonum cuspidatum, grapes, peanuts, red wine, hop pellets, cocoa-containing products and chocolate products. Polydatin exhibits multiple biological properties, such as anti-platelet aggregation, anti-low-density lipoprotein oxidation, cardioprotective activity, anti-inflammatory and immunomodulatory functions. Polydatin shows favorable cytotoxic effects against various tumor cell lines, including cervical cancer cells, liver cancer cells, and nasopharyngeal carcinoma cells.
    (E/Z)-Polydatin
  • HY-101445B
    (S)-Trolox

    (S)-Trolox

    		99.36%
    (S)-Trolox is an analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects.
    (S)-Trolox