Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10679):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-117259S

Valiltramiprosate-d₆
Valiltramiprosate-d₆ (ALZ-801-d₆) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.

HY-152007S

Butyrylcarnitine-d₃ hydrochloride
Butyrylcarnitine-d₃ hydrochloride is deuterium labeled Butyrylcarnitine (HY-113168). Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer.

HY-143679S

4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-¹³C₆
4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-13C6 is the ¹³C labeled isotope of 4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate.

HY-17355BS

Dexpramipexole-d₃ dihydrochloride
Dexpramipexole-d₃ ((R)-Pramipexole-d₃) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

HY-W110726S1

1-Octen-3-one-d₃
1-Octen-3-one-d₃ is deuterated labeled 1-Octen-3-one.

HY-117171S

Proquinazid-(propoxy-d₇)
Proquinazid-(propoxy-d₇) (6-Iodo-2-propoxy-d₇-3-propyl-4(3H)-quinazolinone) is deuterium labeled Proquinazid.

HY-N5142S1

α-Terpineol-d6
α-Terpineol-d₆ is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation.

HY-W343292S1

2-Methylbutyl acetate-d₃
2-Methylbutyl acetate-d₃ is deuterated labeled 2-Methylbutyl acetate.

HY-B0482S1

Acemetacin-¹³C₆
Acemetacin-¹³C₆ (TVX 1322-¹³C₆) is ¹³C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

HY-B1881S

Pirimiphos-methyl-d₆
Pirimiphos-methyl-d₆ is the deuterium labeled Pirimiphos-methyl (HY-B1881). Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.

HY-160471S

N-Nitrososertraline-d₃
N-Nitrososertraline-d3 is a Sertraline isotope labeled with deuterium and nitrogen-15. N-Nitrososertraline-d3 can be used to track the metabolism and pharmacokinetics of Sertraline in vivo.

HY-W722107

Timonacic-d₄
Timonacic-d₄ (1,3-Thiazolidine-4-carboxylic acid-d₄) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases.

HY-B0071S1

Granisetron-d₄
Granisetron-d₄ (BRL 43694-d₄) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-13575S1

Blonanserin-d₅
Blonanserin-d₅ (AD-5423-d₅) is a deuterium labeled Blonanserin (HY-13575). Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.

HY-B0580S2

Ketorolac-¹³C₆
Ketorolac-¹³C₆ (RS37619-¹³C₆) is ¹³C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research.

HY-142107S

9-cis,13-cis-Retinol-d₅
9-cis,13-cis-Retinol-d₅ is the deuterium labeled 9-cis,13-cis-Retinol.

HY-10873S1

N-Desethyl Sunitinib-d₄ TFA
N-Desethyl Sunitinib-d₄ (SU-12662-d₄) TFA is deuterium-labeled N-Desethyl Sunitinib (HY-10873).

HY-B0149S2

Tranexamic acid-¹³C₆
Tranexamic acid-¹³C₆ (Cyclocapron-¹³C₆) is ¹³C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-13238S2

Dolutegravir-d₅
Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM).

HY-145503S

Decanoyl-L-carnitine-d₉ chloride
Decanoyl-L-carnitine-d₉ (chloride) is deuterium labeled Decanoyl-L-carnitine (chloride). Decanoyl-L-carnitine chloride is an ester derivative of L-carnitine, which is an important cofactor of fatty acid metabolism.

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