Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10678):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W101987S2

Bisphenol A bis(2,3-dihydroxypropyl) ether-d₆
Bisphenol A bis(2,3-dihydroxypropyl) ether-d₆ is deuterium labeled 3,3'-((Propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis(propane-1,2-diol).

HY-W700821

Pramipexole impurity 38-d₃
Pramipexole impurity 38-d₃ is deuterium labeled (R)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide.

HY-W012889S3

DL-Valine-d-1
DL-Valine-d-1 is the deuterium labeled DL-Valine.

HY-P0036S3

Octreotide-¹³C₉，¹⁵N
Octreotide-¹³C₉,¹⁵N (SMS 201-995-¹³C₉,¹⁵N) is ¹³C and ¹⁵N labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.

HY-12199S

Pitolisant-d₁₀
Pitolisant-d₁₀ (Tiprolisant-d₁₀) is deuterium labeled Pitolisant. Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).

HY-Y1010S

Oxiran-2-ylmethanol-d₅
Oxiran-2-ylmethanol-d₅ is the deuterium labeled Oxiran-2-ylmethanol (Glycidol) (HY-Y1010). Oxiran-2-ylmethanol is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.

HY-A0004S

Decitabine-¹³C₅
Decitabine-¹³C₅ (5-Aza-2'-deoxycytidine-¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.

HY-D0932S

Sudan IV-d₆
Sudan IV-d₆ (Solvent Red 24-d₆) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.

HY-W587397S

Benzoic acid, 4,4′-[[6-[[4-[[(1,1-dimethy-d₄
Benzoic acid, 4,4′-[[6-[[4-[[(1,1-dimethy-d₄ is deuterium labeled Benzoic acid, 4,4′-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, 1,1′-bis(2-ethylhexyl) ester.

HY-17430S2

Amprenavir-¹³C₆
Amprenavir-¹³C₆ (VX-478-¹³C₆) is ¹³C labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CL^pro inhibitor with an IC₅₀ of 1.09 μM.

HY-141916S

Glycodeoxycholic acid sulfate-d₄ disodium
Taurodeoxycholic Acid-3-Sulfate-d₄ (Sodium) is the deuterium labeled Taurodeoxycholic Acid-3-Sulfate.

HY-B1276S

Metaproterenol-d₇ hemisulfate
Metaproterenol-d₇ (hemisulfate) is the deuterium labeled Metaproterenol hemisulfate. Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC₅₀ of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.

HY-W726709

Propachlor ESA-d₅ sodium
Propachlor ESA-d₅ (2-[(1-Methylethyl)phenylamino-d₅]-2-oxoethanesulfonic acid) sodiumis deuterium labeled Sodium 2-(isopropyl(phenyl)amino)-2-oxoethane-1-sulfonate.

HY-133680S

β-Tocopherol-d₄
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-W653896

Alternariol-d₂
Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.

HY-113238S1

Lithocholic acid 3-sulfate-d₄（sodium salt）
Lithocholic acid 3-sulfate-d₄（sodium salt） is the deuterium labeled Lithocholic acid 3-sulfate.

HY-176351S

Growth hormone 22, U-¹⁵N
Growth hormone 22, U-¹⁵N is the ¹⁵N-labeled Growth hormone 22.

HY-157050S

3-Hydroxygepirone-d₈
3-Hydroxygepirone-d₈ is deuterium-labeled 3-Hydroxygepirone.

HY-W743379

(S)-N-Nitroso anatabine-d₄
(S)-N-Nitroso anatabine-d₄ is deuterium labeled (S)-N-Nitroso Anatabine.

HY-17425AS1

Valacyclovir-d₄ hydrochloride
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422).

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