Tranylcypromine hemisulfate
Based on 9 publication(s) in Google Scholar
Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 13492-01-8
- Formula: C9H12NO2S0.5
- Molecular Weight:182.23
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
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Chemical Information
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- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) Tranylcypromine hemisulfate
More- Biomaterials. 2019 Feb:193:30-46. [Abstract]
- Stem Cell Res Ther. 2020 Apr 16;11(1):157. [Abstract]
- Biochem Pharmacol. 2025 Sep:239:117073. [Abstract]
- Int Immunopharmacol. 2025 Oct 10:163:115242. [Abstract]
- Int Immunopharmacol. 2025 Jun 26:159:114966. [Abstract]
- Clin Exp Med. 2025 Nov 25;26(1):33. [Abstract]
- Biol Reprod. 2020 Dec 1;103(6):1229-1237. [Abstract]
- Biochem Biophys Res Commun. 2019 May 14;512(4):852-858. [Abstract]
- Patent. US20180263995A1.
Customer Validation & Images
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Others
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WB
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Cell Proliferation/Viability Assay
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Flow Cytometry
Biological Activity
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KDM1/LSD1 |
Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells[1]. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13492-01-8
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Appearance Solid
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Molecular Weight 182.23
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Formula C9H12NO2S0.5
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Color White to off-white
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SMILES
N[C@H]1[C@H](C2=CC=CC=C2)C1.[0.5H2SO4]
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Synonyms
SKF 385 hemisulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Biomaterials
Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. [Abstract]2019 Feb:193:30-46. PMID: 30554025 -
Stem Cell Res Ther
Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone. [Abstract]2020 Apr 16;11(1):157. PMID: 32299508 -
Biochem Pharmacol
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. [Abstract]2025 Sep:239:117073. PMID: 40562117
Tranylcypromine hemisulfate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Sep:239:117073. [Abstract]
Schematic diagram of Triflupromazine and Tranylcypromine hydrochloride alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. LDHA interacts with AMBRA1 via non-metabolic enzyme functions, promoting AMBRA1 ubiquitination and degradation, which leads to cisplatin resistance by regulating the cell cycle and apoptosis.
Tranylcypromine hemisulfate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Sep:239:117073. [Abstract]
Tranylcypromine hydrochloride (0-100 μM) significantly inhibited LDHA expression and increased AMBRA1 protein levels in resistant cell line H1838.
Tranylcypromine hemisulfate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Sep:239:117073. [Abstract]
CCK8 assay evaluating the survival of H1838 treated with serial concentrations of cisplatin in combination with Tranylcypromine hydrochloride (0-100 μM, 48 h).
Tranylcypromine hemisulfate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Sep:239:117073. [Abstract]
Apoptosis analysis in H1838 cells treated with cisplatin accompanied by TRI (5 μM) and Tranylcypromine hydrochloride (50 μM) respectively for 48 h.
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Int Immunopharmacol
Tangeretin protects the kidney from ischemia-reperfusion injury by inhibiting inflammatory response through downregulation of MAOA. [Abstract]2025 Oct 10:163:115242. PMID: 40682983 -
Int Immunopharmacol
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia. [Abstract]2025 Jun 26:159:114966. PMID: 40440957 -
Clin Exp Med
Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]2025 Nov 25;26(1):33. PMID: 41286164 -
Biol Reprod
2020 Dec 1;103(6):1229-1237. PMID: 32902654 -
Biochem Biophys Res Commun
Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells. [Abstract]2019 May 14;512(4):852-858. PMID: 30929918 -
Solvent & Solubility
H2O : 12.5 mg/mL (68.59 mM; Need ultrasonic)
DMSO : 5 mg/mL (27.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 20 mg/mL (109.75 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Protocol
Briefly, the rats are anesthetized with an intraperitoneal injection of a 1:1 mixture of xylazine hydrochloride (4 mg/kg) and ketamine hydrochloride (10 mg/kg). Then, the pupil is dilated with phenylephrine hydrochloride and tropicamide eye drops, and 20 nmol NMDA with or without tranylcypromine is injected into the vitreous cavity. To assess the inhibitory effect of mitogen-activated protein kinase (MAPK), 100 nmol BIRB796 is intravitreally injected at the same time of NMDA injection. The injections are performed under a microscope using a 33-gauge needle connected to a microsyringe; the needle is inserted approximately 1.0 mm behind the corneal limbus. Next, either PBS (vehicle control) or 500 mM tranylcypromine (1000 nmol) mixed with 10 mM NMDA (20 nmol) in a total volume of 2.0 μL is injected into the vitreous cavity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Caraci F, et al. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity. Eur J Pharmacol. 2015 Oct 5;764:256-263. [Content Brief]
[2]. Sun Q, et al. Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016 Apr 9;14:17. [Content Brief]
[3]. Tsutsumi T, et al. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6461-6473. [Content Brief]
[4]. Romanczyk TB, et al. The antidepressant tranylcypromine alters cellular proliferation and migration in the adult goldfish brain. Anat Rec (Hoboken). 2014 Oct;297(10):1919-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 5.4876 mL | 27.4379 mL | 54.8757 mL | 137.1893 mL |
| 5 mM | 1.0975 mL | 5.4876 mL | 10.9751 mL | 27.4379 mL | |
| 10 mM | 0.5488 mL | 2.7438 mL | 5.4876 mL | 13.7189 mL | |
| 15 mM | 0.3658 mL | 1.8292 mL | 3.6584 mL | 9.1460 mL | |
| 20 mM | 0.2744 mL | 1.3719 mL | 2.7438 mL | 6.8595 mL | |
| 25 mM | 0.2195 mL | 1.0975 mL | 2.1950 mL | 5.4876 mL | |
| H2O | 30 mM | 0.1829 mL | 0.9146 mL | 1.8292 mL | 4.5730 mL |
| 40 mM | 0.1372 mL | 0.6859 mL | 1.3719 mL | 3.4297 mL | |
| 50 mM | 0.1098 mL | 0.5488 mL | 1.0975 mL | 2.7438 mL | |
| 60 mM | 0.0915 mL | 0.4573 mL | 0.9146 mL | 2.2865 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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