1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. Troxacitabine

Troxacitabine  (Synonyms: BCH 4556; L-OddC; SPD 758)

Cat. No.: HY-13770
Handling Instructions

Troxacitabine is nucleoside analog with potent anticancer activity.

For research use only. We do not sell to patients.

Troxacitabine Chemical Structure

Troxacitabine Chemical Structure

CAS No. : 145918-75-8

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25 mg USD 880 Ask For Quote & Lead Time
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100 mg USD 2250 Ask For Quote & Lead Time

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Description

Troxacitabine is nucleoside analog with potent anticancer activity.

In Vitro

Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

213.19

Formula

C8H11N3O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N(C=C1)[C@@H]2CO[C@H](CO)O2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
Animal Administration
[3]

Mice[3]

Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Troxacitabine Related Classifications

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Troxacitabine
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HY-13770
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