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Troxacitabine (Synonyms: BCH 4556; L-OddC; SPD 758)

Cat. No.: HY-13770
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Troxacitabine is nucleoside analog with potent anticancer activity.

For research use only. We do not sell to patients.

Troxacitabine Chemical Structure

Troxacitabine Chemical Structure

CAS No. : 145918-75-8

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Troxacitabine is nucleoside analog with potent anticancer activity.

In Vitro

Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2].

In Vivo

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].

Clinical Trial
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Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration


Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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TroxacitabineBCH 4556 L-OddC SPD 758BCH4556BCH-4556SPD758SPD 758SPD-758OthersInhibitorinhibitorinhibit

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