1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Epigenetics
    Stem Cell/Wnt
    Apoptosis
  2. EGFR
    JAK
    Apoptosis
  3. WHI-P154

WHI-P154 

Cat. No.: HY-13895 Purity: 99.20%
Handling Instructions

WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.

For research use only. We do not sell to patients.

WHI-P154 Chemical Structure

WHI-P154 Chemical Structure

CAS No. : 211555-04-3

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10 mM * 1 mL in DMSO USD 117 In-stock
Estimated Time of Arrival: December 31
10 mg USD 106 In-stock
Estimated Time of Arrival: December 31
50 mg USD 451 In-stock
Estimated Time of Arrival: December 31
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Description

WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.

IC50 & Target[1]

EGFR

4 nM (IC50)

JAK3

1.8 μM (IC50)

In Vitro

WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively[1]. WHI-P154 significantly enhances the sensitivity of ABCG2-overexpressing cells to its substrates. WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-, ABCC2 or ABCC10-mediated drug resistance. Moreover, WHI-P154 (4 μM) causes a significant increase in the intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. WHI-P154 alters the expression levels rather than the localization of the ABCG2 protein in ABCG2-overexpressing cells[2].

Molecular Weight

376.20

Formula

C₁₆H₁₄BrN₃O₃

CAS No.

211555-04-3

SMILES

OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (124.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6582 mL 13.2908 mL 26.5816 mL
5 mM 0.5316 mL 2.6582 mL 5.3163 mL
10 mM 0.2658 mL 1.3291 mL 2.6582 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.20%

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Keywords:

WHI-P154EGFRJAKApoptosisEpidermal growth factor receptorErbB-1HER1Janus kinaseInhibitorinhibitorinhibit

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WHI-P154
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