2. PI3K/Akt/mTOR Neuronal Signaling Membrane Transporter/Ion Channel
  3. mTOR nAChR
  4. (2S,6S)-Hydroxynorketamine hydrochloride

(2S,6S)-Hydroxynorketamine hydrochloride  (Synonyms: (2S,6S)-HNK hydrochloride)

製品番号: HY-101955 純度: 99.30%
COA 取扱説明書 Technical Support

(2S,6S)-Hydroxynorketamine hydrochloride is a neurorelaxant with potential antidepressant and analgesic effects. (2S,6S)-Hydroxynorketamine hydrochloride can activate the mTOR pathway, increase the phosphorylation level of downstream targets, and antagonize α7-nicotinic acetylcholine receptor (nAChR) to exert neuroactive properties.

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(2S,6S)-Hydroxynorketamine hydrochloride

(2S,6S)-Hydroxynorketamine hydrochloride 構造式

CAS 番号 : 1430202-70-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 264 在庫あり
Solution
10 mM * 1 mL in DMSO USD 264 在庫あり
Solid
5 mg $240 在庫あり
10 mg $380 在庫あり
25 mg $760 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of (2S,6S)-Hydroxynorketamine hydrochloride:

(2S,6S)-Hydroxynorketamine hydrochloride 関連抗体

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製品説明

(2S,6S)-Hydroxynorketamine hydrochloride is a neurorelaxant with potential antidepressant and analgesic effects. (2S,6S)-Hydroxynorketamine hydrochloride can activate the mTOR pathway, increase the phosphorylation level of downstream targets, and antagonize α7-nicotinic acetylcholine receptor (nAChR) to exert neuroactive properties[1].

分子量

276.16

分子式

C12H15Cl2NO2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@]1(C([C@H](CCC1)O)=O)C2=C(C=CC=C2)Cl.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 50 mg/mL (181.05 mM)

DMSO : 50 mg/mL (181.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6211 mL 18.1054 mL 36.2109 mL
5 mM 0.7242 mL 3.6211 mL 7.2422 mL
10 mM 0.3621 mL 1.8105 mL 3.6211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.30%

COA (252 KB) HNMR (255 KB) LCMS (89 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.6211 mL 18.1054 mL 36.2109 mL 90.5272 mL
5 mM 0.7242 mL 3.6211 mL 7.2422 mL 18.1054 mL
10 mM 0.3621 mL 1.8105 mL 3.6211 mL 9.0527 mL
15 mM 0.2414 mL 1.2070 mL 2.4141 mL 6.0351 mL
20 mM 0.1811 mL 0.9053 mL 1.8105 mL 4.5264 mL
25 mM 0.1448 mL 0.7242 mL 1.4484 mL 3.6211 mL
30 mM 0.1207 mL 0.6035 mL 1.2070 mL 3.0176 mL
40 mM 0.0905 mL 0.4526 mL 0.9053 mL 2.2632 mL
50 mM 0.0724 mL 0.3621 mL 0.7242 mL 1.8105 mL
60 mM 0.0604 mL 0.3018 mL 0.6035 mL 1.5088 mL
80 mM 0.0453 mL 0.2263 mL 0.4526 mL 1.1316 mL
100 mM 0.0362 mL 0.1811 mL 0.3621 mL 0.9053 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(2S,6S)-Hydroxynorketamine hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2S,6S)-Hydroxynorketamine1430202-70-2(2S,6S)-HNKmTORnAChRMammalian target of RapamycinNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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製品名:
(2S,6S)-Hydroxynorketamine hydrochloride
製品番号:
HY-101955
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