2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. (S)-Willardiine

(S)-Willardiine  (Synonyms: (-)-Willardiine)

Cat. No.: HY-12499 Purity: 98.93%
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Handling Instructions Technical Support

(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system.

For research use only. We do not sell to patients.

(S)-Willardiine

(S)-Willardiine Chemical Structure

CAS No. : 21416-43-3

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(S)-Willardiine Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system[1].

IC50 & Target[1]

AMPA Receptor

 

Kainate Receptor

 

Cellular Effect
Cell Line Type Value Description References
Oocyte EC50
11.5 μM
Compound: (S)-2a, (S)-willardiine
Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
[PMID: 18811139]
In Vitro

(S)-Willardiine (10-12-10-3 M; 60 min) binds with low affinity to homomeric hGluR1, hGluR2, and hGluR4 receptors, displaying the weakest potency among tested willardiine analogs on these human AMPA receptor subtypes[1].
(S)-Willardiine (10-12-10-3 M; 60 min) binds with very low affinity to homomeric hGluR5 receptors, displaying the weakest potency among tested willardiine analogs on this human kainate receptor subtype[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Willardiine Related Antibodies
Molecular Weight

199.17

Formula

C7H9N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation

Purity: 98.93%

SDS (393 KB)

COA (249 KB) HNMR (211 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
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(S)-Willardiine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Willardiine21416-43-3(-)-WillardiineiGluRIonotropic glutamate receptorscentral nervous systemglutamate receptor agonisthuman kainate receptor subtypehGluR5hGluR1hGluR4glutamate receptor subunit distributionhGluR2human AMPA receptor subtypesInhibitorinhibitorinhibit

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