2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Endogenous Metabolite
  4. (±)-1,2-Propanediol

プロピレングリコール  (Synonyms: (±)-1,2-Propanediol; 1,2-(RS)-Propanediol; 1,2-Propylene glycol; Propylene glycol)

製品番号: HY-Y0921 純度: 99.97%
COA 取扱説明書 Technical Support

(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.

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(±)-1,2-Propanediol

プロピレングリコール 構造式

CAS 番号 : 57-55-6

容量 価格（税別） 在庫状況 数量
Solvent
10 mM * 1 mL in DMSO USD 66 在庫あり
Solvent
100 mL USD 60 在庫あり
Solvent
500 mL USD 90 在庫あり
Solvent
1000 mL USD 110 在庫あり
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10L   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of (±)-1,2-Propanediol:

プロピレングリコール 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

(±)-1,2-Propanediol (Propylene glycol) is a frequently used excipient in many drug formulations to increase the solubility and/or stability of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

プロピレングリコール 関連抗体
体内実験

Studies in animal models show that (±)-1,2-Propanediol is rapidly absorbed (within ~1 h) after oral or intravenous administration. Upon absorption, (±)-1,2-Propanediol is uniformly distributed in total body water without a significant distribution to specific tissues. (±)-1,2-Propanediol is primarily metabolized in the liver by alcohol dehydrogenase (ADH; EC 1.1.1.1) into lactaldehyde, which is then metabolized by aldehyde dehydrogenase (ALDH; EC 1.2.1.3) into lactic acid. It is further metabolized by lactate dehydrogenase (LDH; EC 1.1.1.27) into pyruvate that is eventually metabolized into CO2 and H2O within the citric acid cycle[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

76.09

分子式

C3H8O2
CAS 番号
Appearance

Liquid (Density: 1.036 g/cm3)

Color

Colorless to light yellow

SMILES

CC(O)CO
Initial Source

Clostridium strain AK1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (1314.23 mM; Need ultrasonic)

DMSO : 100 mg/mL (1314.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.1423 mL 65.7117 mL 131.4233 mL
5 mM 2.6285 mL 13.1423 mL 26.2847 mL
10 mM 1.3142 mL 6.5712 mL 13.1423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.97%

COA (245 KB) HNMR (115 KB) GC (246 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 13.1423 mL 65.7117 mL 131.4233 mL 328.5583 mL
5 mM 2.6285 mL 13.1423 mL 26.2847 mL 65.7117 mL
10 mM 1.3142 mL 6.5712 mL 13.1423 mL 32.8558 mL
15 mM 0.8762 mL 4.3808 mL 8.7616 mL 21.9039 mL
20 mM 0.6571 mL 3.2856 mL 6.5712 mL 16.4279 mL
25 mM 0.5257 mL 2.6285 mL 5.2569 mL 13.1423 mL
30 mM 0.4381 mL 2.1904 mL 4.3808 mL 10.9519 mL
40 mM 0.3286 mL 1.6428 mL 3.2856 mL 8.2140 mL
50 mM 0.2628 mL 1.3142 mL 2.6285 mL 6.5712 mL
60 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4760 mL
80 mM 0.1643 mL 0.8214 mL 1.6428 mL 4.1070 mL
100 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2856 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(±)-1,2-Propanediol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-1,2-Propanediol57-55-61,2-(RS)-Propanediol 1,2-Propylene glycol Propylene glycolEnvironmental PollutantsEndogenous MetaboliteEnvironmental Contaminants1,2-Propanediol (propylene glycol)ZebrafishBehaviorNeural and vascular developmentInhibitorinhibitorinhibit

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