(±)-1,2-Propanediol-d6
Based on 1 Customer Validation
(±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 52910-80-2
- Formula: C3H2D6O2
- Molecular Weight:82.13
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 52910-80-2
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Unlabeled Cas 57-55-6
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Appearance Liquid (Density: 1.118 g/cm3)
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Molecular Weight 82.13
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Formula C3H2D6O2
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Color Colorless to light yellow
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SMILES
OC([2H])([2H])C(O)([2H])C([2H])([2H])[2H]
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Synonyms
1,2-(RS)-Propanediol-d6; 1,2-Propylene glycol-d6; Propylene glycol-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 250 mg/mL (3043.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 12.1758 mL | 60.8791 mL | 121.7582 mL | 304.3955 mL |
| 5 mM | 2.4352 mL | 12.1758 mL | 24.3516 mL | 60.8791 mL | |
| 10 mM | 1.2176 mL | 6.0879 mL | 12.1758 mL | 30.4395 mL | |
| 15 mM | 0.8117 mL | 4.0586 mL | 8.1172 mL | 20.2930 mL | |
| 20 mM | 0.6088 mL | 3.0440 mL | 6.0879 mL | 15.2198 mL | |
| 25 mM | 0.4870 mL | 2.4352 mL | 4.8703 mL | 12.1758 mL | |
| 30 mM | 0.4059 mL | 2.0293 mL | 4.0586 mL | 10.1465 mL | |
| 40 mM | 0.3044 mL | 1.5220 mL | 3.0440 mL | 7.6099 mL | |
| 50 mM | 0.2435 mL | 1.2176 mL | 2.4352 mL | 6.0879 mL | |
| 60 mM | 0.2029 mL | 1.0147 mL | 2.0293 mL | 5.0733 mL | |
| 80 mM | 0.1522 mL | 0.7610 mL | 1.5220 mL | 3.8049 mL | |
| 100 mM | 0.1218 mL | 0.6088 mL | 1.2176 mL | 3.0440 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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